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Recombinant Human Activin A Receptor, Type IB

Cat. No.: ACVR1B-2596H
Product Overview: Recombinant Human Activin A Receptor, Type IB is expressed in BTI-Tn-5B1-4 cells.
Description: Activin B is a TGF-β family member that exhibits a wide range of biological activities including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II). Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues.
Source: BTI-Tn-5B1-4 cells.
Purity: Greater than 98% (determined by SDS-PAGE and HPLC analysis).
Molecular Mass: 25.6 kDa.
Specific Activity: ≥5 x 105IU/mg.
Endotoxin Level: < 0.1 ng per μg of rHu Activin B (1 EU/μg).
Biological Activity: The ED50as determined by its ability to inhibit the proliferation of murine MPC-11 cells is < 2 ng/ml, corresponding to a specific activity of > 5 x 105units/mg.
Formulation: Lyophilized from a sterile-filtered solution with no additives.
Reconstitution: Please Note: Always centrifuge product briefly before opening vial. The lyophilized protein should be reconstituted in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.
Storage: The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted rHu Activin B should be used immediately or stored long-term in undiluted working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
Gene Name: ACVR1B activin A receptor, type IB [ Homo sapiens ]
Synonyms: ACVR1B; activin A receptor, type IB; ALK4; SKR2; ACTRIB; ACVRLK4; activin receptor-like kinase 4; activin A receptor, type II-like kinase 4; serine(threonine) protein kinase receptor R2; ACTR-IB; ALK-4; ActRIB; EC 2.7.11.30; Activin receptor-like kinase 4; Serine/threonine-protein kinase receptor R2; activin A type IB receptor
Gene ID: 91
mRNA Refseq: NM_004302
Protein Refseq: NP_004293
MIM: 601300
UniProt ID: P36896
Chromosome Location: 12q13
Pathway: Adherens junction; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Endocytosis; MAPK signaling pathway; Pancreatic cancer; Pathways in cancer; TGF-beta signaling pathway
Function: ATP binding; SMAD binding; activin binding; activin receptor activity, type I; growth factor binding; magnesium ion binding; manganese ion binding; nucleotide binding; protein serine/threonine kinase activity; receptor activity; transferase activity; ubiquitin protein ligase binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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