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Recombinant Human PTK2B, GST-tagged

Cat.No. : PTK2B-743H
Product Overview : Recombinant Human PTK2B with GST tag is expressed in Baculovirus.
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  • Gene Information
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Cat. No. : PTK2B-743H
Description : This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
Source : Baculovirus.
Purity : 74 %, The purity was assessed by SDS-PAGE/CBB staining.
Storage And Handling : Store at -80oC. Avoid repeating freeze-thaws.
Gene Name : PTK2B PTK2B protein tyrosine kinase 2 beta [ Homo sapiens ]
Synonyms : PTK2B; PTK2B protein tyrosine kinase 2 beta; PTK2B protein tyrosine kinase 2 beta; CAK beta; calcium-dependent tyrosine kinase; cell adhesion kinase beta; focal adhesion kinase 2; proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; related adhesion focal tyrosine kinase; EC 2.7.10.2
Gene ID : 2185
mRNA Refseq : NM_004103
Protein Refseq : NP_004094
MIM : 601212
UniProt ID : Q14289
Chromosome Location : 8p21.1
Pathway : Calcium signaling pathway; Chemokine signaling pathway; GnRH signaling pathway; Leukocyte transendothelial migration; Natural killer cell mediated cytotoxicity
Function : 3-phosphoinositide-dependent protein kinase binding; ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein complex binding; signal transducer activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is PTK2B protein expression measured in clinical settings? 11/19/2022

PTK2B protein expression can be assessed using techniques like Western blotting and immunohistochemistry.

What are the challenges in developing PTK2B-targeted therapies? 10/27/2022

One of the challenges is achieving specificity in targeting PTK2B without affecting other related proteins or pathways.

Are there any drugs that target PTK2B protein? 06/22/2019

Several small molecule inhibitors targeting PTK2B are being developed as potential therapeutics for cancer and other diseases.

Can PTK2B protein be used as a diagnostic marker for any diseases? 06/09/2019

PTK2B protein expression has been explored as a potential diagnostic marker for certain cancers and neurodegenerative disorders.

Can PTK2B protein be targeted for therapeutic purposes? 12/21/2018

Yes, PTK2B is a potential therapeutic target for cancer, neurodegenerative diseases, and cardiovascular conditions.

Customer Reviews (3)

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Reviews
11/10/2021

    PTK2B protein is highly recommended for researchers, as it demonstrates excellent performance in WB experiments and has proven useful in protein electron microscopy structure analysis.

    04/28/2021

      PTK2B protein is highly recommended for researchers due to its excellent performance in various assays, particularly in Western blotting (WB) experiments, and its applicability in protein electron microscopy structure analysis.

      07/04/2018

        It enables accurate detection and quantification of PTK2B protein levels in samples, providing crucial insights into its expression, regulation, and potential functional changes under different experimental conditions.

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