Recombinant Human DDC, T7-tagged

• Cat.No.: DDC-848H
• Product Overview: Recombinant Human DDC was produced in E.coli with a T7 tag at N-terminus. MW = 53894 Da (1-480 aa).

Specification

• Cat. No.: DDC-848H
• Description: Dopa Decarboxylase (DDC), also known as AADC and Aromatic-L-amino acid decarboxylase, is a 54 kDa member of the group II decarboxylase family of proteins.It is a vitamin B6-dependent homodimeric enzyme that catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Since L-DOPA is regularly used to treat the symptoms of Parkinson"s disease, the catalytic pathway is of particular research interest. Defects of DDC are associated with severe developmental delay, oculogyric crises (OGC), as well as autosomal recessive disorder AADC deficiency, an early onset inborn error in neurotransmitter metabolism which can lead to catecholamine and serotonin deficiency.
• Source: E.coli.
• Form: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT.
• Purity: 95%.
• Clonality: N/A.
• Applications: MS. SDS.

Gene Information

• Gene Name: DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) [ Homo sapiens ]
• Synonyms: DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase); AADC; Aromatic-L-amino-acid decarboxylase; DOPA decarboxylase; EC 4.1.1.28; L-Dopa decarboxylase; aromatic L-amino acid decarboxylase
• Gene ID: 1644
• mRNA Refseq: NM_000790
• Protein Refseq: NP_000781
• MIM: 107930
• UniProt ID: P20711
• Chromosome Location: 7p11
• Pathway: Betalain biosynthesis; Biosynthesis of alkaloids derived from shikimate pathway; Histidine metabolism; Isoquinoline alkaloid biosynthesis; Metabolic pathways; Metabolic pathways; Phenylalanine metabolism; Tryptophan metabolism; Synaptic Transmission
• Function: aromatic-L-amino-acid decarboxylase activity; lyase activity; protein binding; pyridoxal phosphate binding