"GMPR2" Related Products

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Recombinant Human Guanosine Monophosphate Reductase 2, His-tagged

Cat. No.: GMPR2-788H
Product Overview: Recombinant human GMPR2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW =40 kDa (368aa), confirmed by MALDI-TOF.
Description: Guanosine monophosphate reductase 2, also known as GMPR2, is the only known metabolic step by which guanine nucleotides can be converted to the pivotal precursor of both adenine and guanine nucleotides. GMPR2 catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP, and plays a critical role in re-utilization of free intracellular bases and purine nucleosides.
Source: E.coli.
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFSFRN SKQTYSGVPI IAANMDTVGT FEMAKVLCKF SLFTAVHKHY SLVQWQEFAG QNPDCLEHLA ASSGTGSSDF EQLEQILEAI PQVKYICLDV ANGYSEHFVE FVKDVRKRFP QHTIMAGNVV TGEMVEELIL SGADIIKVGI GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM LGGMLAGHSE SGGELIERDG KKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD VEHTIRDILG GIRSTCTYVG AAKLKELSRR TTFIRVTQQV NPIFSEAC
Purity: > 90% by SDS – PAGE.
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol.
Concentration: 1mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: GMPR2 guanosine monophosphate reductase 2 [ Homo sapiens ]
Synonyms: GMPR2; guanosine monophosphate reductase 2; MGC830; MGC15084; GMP reductase 2; guanosine monophosphate reductase isolog; guanosine 5"-monophosphate oxidoreductase 2; EC 1.7.1.7
Gene ID: 51292
mRNA Refseq: NM_001002000
Protein Refseq: NP_001002000
MIM: 610781
UniProt ID: Q9P2T1
Chromosome Location: 14q12
Pathway: Purine metabolism
Function: GMP reductase activity; metal ion binding; oxidoreductase activity

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