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Recombinant Human Iinterferon, Beta 1, Fibroblast

Cat. No. : IFNB1-93H
Product Overview : Recombinant Human interferon-beta-1b (IFN-β-1b) produced in Pseudomonas fluorescens contains a Cys17Ser substitution; and after expression, lacks the N-terminal methionine. MW = 19.9 kDa.
Description : Human interferon beta (IFN-β) is produced in many cell types in response to viral infection, microorganisms, double-stranded RNA, and certain cytokines. IFN-β is known to regulate genes involved in antiviral, antiproliferative, and immunomodulatory activities. Endogenously expressed IFN-β-1a is a glycoprotein; however, nonglycosylated versions have demonstrated similar activities.
Source : Pseudomonas fluorescens.
N-terminal Sequence : Ser-Tyr-Asn-Leu-Leu.
Purity : >97%, by SDS-CGE under reducing condition.
Formulation : Lyophilized with sucrose and glycine.
Endotoxin Level : <1.0 EU per 1 μg of the protein by the LAL method.
Activity : Measured in a viral inhibition (CPE) assay using EMC virus on A549 cells. Measured in an interferon receptor-2 binding assay.
Storage : Store at 2-8°C upon receipt, preferably desiccated. Reconstitute aseptically in sterile 20 mM acetic acid, pH 4.0, to a final IFN-β concentration of 0.15-0.25 mg/mL. A carrier (such as albumin) is recommended if further dilution is needed. Store reconstituted IFN-β at -20°C (not in a frost-free freezer). Avoid repeated freeze-thaw.
Gene Name : IFNB1 interferon, beta 1, fibroblast [ Homo sapiens ]
Synonyms : IFNB1; interferon, beta 1, fibroblast; IFB; IFF; IFNB; MGC96956; interferon beta; IFN-beta; fibroblast interferon
Gene ID : 3456
mRNA Refseq : NM_002176
Protein Refseq : NP_002167
MIM : 147640
UniProt ID : P01574
Chromosome Location : 9p21
Pathway : Chagas disease; Cytokine-cytokine receptor interaction; Cytosolic DNA-sensing pathway; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway
Function : cytokine activity; interferon-alpha/beta receptor binding; transcription corepressor activity

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