Recombinant Human Deoxycytidine Kinase, His-tagged

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Recombinant Human Deoxycytidine Kinase, His-tagged

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Cat. No. : DCK-795H
Product Overview : Recombinant human DCK protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. MW = 34.6 kDa(296aa), confirmed by MALDI-TOF.
Description : DCKis a key enzyme in the salvage of deoxyribonucleosides and in the activation of clinically relevant nucleoside analogues. This protein is responsible for the 5`-phosphorylation of purine and pyrimidine deoxynucleosides to the corresponding monophosphates using ATP or UTP as phosphate donors. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives.
Source : E.coli.
Sequences Of Amino Acids : MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMATP PKRSCPSFSA SSEGTRIKKI SIEGNIAAGK STFVNILKQL CEDWEVVPEP VARWCNVQST QDEFEELTMS QKNGGNVLQM MYEKPERWSF TFQTYACLSR IRAQLASLNG KLKDAEKPVL FFERSVYSDR YIFASNLYES ECMNETEWTI YQDWHDWMNN QFGQSLELDG IIYLQATPET CLHRIYLRGR NEEQGIPLEY LEKLHYKHES WLLHRTLKTN FDYLQEVPIL TLDVNEDFKD KYESLVEKVK EFLSTL
Purity : > 90% by SDS – PAGE.
Form : Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 1 mM DTT, 0.1 mM PMSF, 2mM EDTA, 10% Glycerol.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
PDB rendering based on 1p5z. :

Gene Name : DCK deoxycytidine kinase [ Homo sapiens ]
Synonyms : DCK; deoxycytidine kinase; MGC117410; MGC138632; OTTHUMP00000219118; OTTHUMP00000219119; EC 2.7.1.74
Gene ID : 1633
mRNA Refseq : NM_000788
Protein Refseq : NP_000779
MIM : 125450
UniProt ID : P27707
Chromosome Location : 4q13.3-q21.1
Pathway : Purine metabolism; Pyrimidine metabolism
Function : ATP binding; deoxycytidine kinase activity; kinase activity; nucleotide binding; phosphotransferase activity, alcohol group as acceptor; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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