"STK4" Related Products

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Recombinant Human Serine/Threonine Kinase 4, GST-His

Cat. No.: STK4-709H
Product Overview: Recombinant Human STK4, amino acids M3-F487, Nterminal GST-HIS6 fusion protein with a 3C cleavage site, was expressed inSf9insect cells. MW =86,340 Da.
Description: The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it"s possible that this protein induces the chromatin condensation observed in this process.
Source: Baculovirus infected Sf9 cells.
Purification: GST-Affinity Chromatography.
Product Identity: MST1 was confirmed as MST1 by mass spectroscopy LC-ESI-MS/MS.
Storage Buffer: 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol.
Concentration: 0.306 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
Specific Activity: 322 pmol/μg×min.
Storage: -80°C. Avoid repeated freeze-thaw cycles!
Gene Name: STK4 serine/threonine kinase 4 [ Homo sapiens ]
Synonyms: STK4; serine/threonine kinase 4; KRS2; MST1; YSK3; DKFZp686A2068; yeast Ste20-like; mammalian sterile 20-like 1; kinase responsive to stress 2; dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2)); EC 2.7.11.1; MST-1; OTTHUMP00000043418; Mammalian STE20-like protein kinase 1; STE20-like kinase MST1; Serine/threonine-protein kinase Krs-2; Serine/threonine-protein kinase 4
Gene ID: 6789
mRNA Refseq: NM_006282
Protein Refseq: NP_006273
MIM: 604965
UniProt ID: Q13043
Chromosome Location: 20q11.2-q13.2
Pathway: MAPK signaling pathway; Non-small cell lung cancer; Pathways in cancer
Function: ATP binding; magnesium ion binding; nucleotide binding; protein homodimerization activity; protein serine/threonine kinase activity; transcription factor binding; transferase activity

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