"TGFBR1" Related Products

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Recombinant Human TGFBR1, GST-His

Cat. No. : TGFBR1-716H
Product Overview : Recombinant Human TGFB-R1, C-terminal fragment, amino acids T200-M503, N-terminal GST-HIS6 fusion protein with a Thrombin cleavage site, was expressed inSf9insect cells.MW = 64,168 Da.
Description : The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
Source : Baculovirus infected Sf9 cells.
Purification : GST-Affinity Chromatography.
Product Identity : TGFB-R1 was confirmed as TGFB-R1 by mass spectroscopy LCESI-MS/MS.
Storage Buffer : 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol.
Concentration : 0.193 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
Specific Activity : 501 pmol/μg×min.
Storage : -80°C. Avoid repeated freeze-thaw cycles!
Gene Name : TGFBR1 transforming growth factor, beta receptor 1 [ Homo sapiens ]
Synonyms : TGFBR1; transforming growth factor, beta receptor 1; AAT5; ALK5; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4; 9q22; activin receptor-like kinase 5; transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; activin A receptor type II-like kinase, 53Kd; activin A receptor type II-like kinase, 53kDa; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); EC 2.7.11.30; TGF-beta receptor type-1; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TGF-beta type I receptor; TbetaR-I; OTTHUMP00000021783
Gene ID : 7046
mRNA Refseq : NM_001130916
Protein Refseq : NP_001124388
MIM : 190181
UniProt ID : P36897
Chromosome Location : 9q22
Pathway : Adherens junction; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Endocytosis; MAPK signaling pathway; Pancreatic cancer; Pathways in cancer; TGF-beta signaling pathway
Function : ATP binding; SMAD binding; magnesium ion binding; manganese ion binding; nucleotide binding; protein complex binding; protein heterodimerization activity; protein serine/threonine kinase activity; receptor activity; transferase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; type II transforming growth factor beta receptor binding; ubiquitin protein ligase binding

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