"PIM1" Related Products

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Recombinant Human Pim-1 Oncogene, GST-His

Cat. No. : PIM1-726H
Product Overview : Recombinant Human PIM1, Amino acids M1-K313, N-terminally fused to GST-HIS6-Thrombin cleavage site, was expressed inSf9cells. MW = 65,423 Da.
Description : Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. The pim-1 oncogene was first described in relation to murine T-cell lymphomas, as it was the locus most frequently activated by the Moloney murine leukemia virus.[4] Subsequently, the oncogene has been implicated in multiple human cancers, including prostate cancer, acute myeloid leukemia and other hematopoietic malignancies.
Source : Baculovirus infected Sf9 cells.
Purification : One-step affinity purification using GSH-agarose.
Product Identity : PIM1 was confirmed as human PIM1 by mass spectroscopy LC-ESIMS/ MS (Protagen AG, Germany).
Storage Buffer : 50 mM Tris-HCl, pH 8.0; 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol.
Concentration : 0.185 μg/μl (Bradford method using BSA [Sigma, cat#A-7638, Lot 79H7641] as standard protein).
Specific Activity : 273 pmol/μg×min.
Storage : -80°C. Avoid repeated freeze-thaw cycles!
PDB rendering based on 1xqz. :

Gene Name : PIM1 pim-1 oncogene [ Homo sapiens ]
Synonyms : PIM1; pim-1 oncogene; PIM; Proto-oncogene serine/threonine-protein kinase Pim-1; EC 2.7.11.1
Gene ID : 5292
mRNA Refseq : NM_002648
Protein Refseq : NP_002639
MIM : 164960
UniProt ID : P11309
Chromosome Location : 6p21
Pathway : Acute myeloid leukemia; Jak-STAT signaling pathway
Function : ATP binding; nucleotide binding; transferase activity; manganese ion binding; protein serine/threonine kinase activity; metal ion binding; transcription factor binding

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