Recombinant Human IKBKB, GST-His

• Cat.No.: IKBKB-2661H
• Product Overview: Recombinant Human IKK-beta, full length, amino acids M1-S756, N-terminal GST-HIS6 fusion protein with a Thrombin cleavage site, expressed inSf9 insect cells.

Specification

• Cat. No.: IKBKB-2661H
• Description: IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta) gene.
• Source: Sf9 insect cells.
• Purification: Immobilized Metal Affinity Chromatography.
• Product Identity: IKK-beta was confirmed as IKK-beta by mass spectroscopy LCESI-MS/MS.
• MW: 120.201 Da.
• Storage Buffer: 50 mM Tris-HCl, pH 7.5; 100 mM NaCl, 5 mM DTT, 20% glycerol.
• Concentration: 0.695 μg/μl.
• Specific Activity: 2 pmol/μg×min.
• Storage: -80°C. Avoid repeated freeze-thaw cycles!

Gene Information

• Gene Name: IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [ Homo sapiens ]
• Synonyms:
  IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; inhibitor of nuclear factor kappa-B kinase subunit beta; nuclear factor NF-kappa-B inhibitor kinase beta; IKK2; IKKB; NFKBIKB; FLJ33771; FLJ36218; FLJ38368; FLJ40509; IKK-beta; MGC131801; EC 2.7.11.10
• Gene ID: 3551
• mRNA Refseq: NM_001190720
• Protein Refseq: NP_001177649
• MIM: 603258
• UniProt ID: O14920
• Chromosome Location: 8p11.2
• Pathway: Acute myeloid leukemia; Colorectal cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Focal adhesion; GnRH signaling pathway; Insulin signaling pathway; MAPK signaling pathway; NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Pancreatic cancer; Pathways in cancer; Progesterone-mediated oocyte maturation; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway; Type II diabetes mellitus
• Function: ATP binding; IkappaB kinase activity; identical protein binding; nucleotide binding; protein heterodimerization activity; transcription activator activity; transferase activity