"IGFBP3" Related Products

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Recombinant Human Insulin-Like Growth Factor Binding Protein 3

Cat. No.: IGFBP3-2716H
Product Overview: Recombinant Human Insulin-Like Growth Factor Binding Protein 3 is expressed inhuman cells.
Description: Human Insulin-like Growth Factor Binding Protein-3 (rhIGFBP-3) is a 264 amino acid glycosylated protein that is one of the six "classical" IGF binding proteins. These binding proteins have an important role in stabilizing and regulating the activity of IGFs in vivo. Human IGFBP-3 is a 40-44 kDa glycoprotein that is the most abundant IGFBP in serum and milk. It is produced by non-parenchymal hepatic cells and circulates in serum, binding IGF-I or IGF-II in conjunction with an acid labile subunit (ALS) to form a 150 kDa circulating complex at a serum concentration of about 100 nM. Free IGF-I has a half-life of ~10 min in serum. This can be increased to ~25 min if bound to IGFBP-3 and to ~15 h if complexed with IGFBP-3 and ALS.
Source: Produced recombinantly inhuman cells. Purified by affinity chromatography and HPLC.
Molecular Weight: 43-45 kDa.
Appearance: Lyophilized white powder.
Purity: > 95% human IGFBP-3 (as determined by HPLC and N-terminal sequence).
Biological Activity: Characteristic doublet of glycoforms detected by immuno- blotting using an antibody specific for IGFBP-3.
State: Dried from 1 M acetic acid.
Reconstitution: Reconstitute in 75 µl 10 mM HCl at a concentration of 0.2 mg/ml. Aliquot, snap freeze and store at -80°C. Avoid freeze-thaw cycles.
Storage/Stability: At least 2 years at 2-4°C (lyophilized).
Gene Name: IGFBP3 insulin-like growth factor binding protein 3 [ Homo sapiens ]
Synonyms: IGFBP3; IGFBP-3; BP-53; IBP3; IBP-3; insulin-like growth factor binding protein 3; binding protein 29; binding protein 53; IGF-binding protein 3; acid stable subunit of the 140 K IGF complex; growth hormone-dependent binding protein; Growth-hormone-dependant binding protein
Gene ID: 3486
mRNA Refseq: NM_000598
Protein Refseq: NP_000589
MIM: 146732
UniProt ID: P17936
Chromosome Location: 7p13-p12
Pathway: p53 signaling pathway
Function: insulin-like growth factor I binding; metal ion binding; protein tyrosine phosphatase activator activity

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