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Recombinant Rat Vascular Endothelial Growth Factor C

Cat. No.: Vegfc-454R
Product Overview: Recombinant Rat Vascular Endothelial Growth Factor C is expressed inInsect cells.
Description: Rat VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. rRa VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although rRa VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A. rRa VEGF-C contains 129 amino acids residues. As a result of glycosylation VEGF-C migrates as an 18-24 kDa protein in SDS-PAGE under reducing conditions.
Source: Insect cells.
Molecular Weight: 18-24 kDa.
Endotoxin Level: < 0.1 ng per µg of rRa VEGF-C (1EU/µg).
Purity: > 90% as determined by SDS-PAGE, RP-HPLC and AEX-FPLC.
Biological Activity: Measured by its ability to stimulate phosphorylation of the VEGFR-3/FLT-4 receptor in porcine aortic endothelial cells. The ED50for this effect is typically 200-300 ng/ml.
Formulation: Lyophilized protein from a concentrated solution with BSA.
Reconstitution: Please Note: Always centrifuge product before opening the vial. The lyophilized protein should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.
Storage/Stability: The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted VEGF-C should be used immediately or stored long-term in undiluted working aliquots at –20°C. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid repeated freeze / thaw cycles.
Gene Name: Vegfc vascular endothelial growth factor C [ Rattus norvegicus ]
Synonyms: Vegfc; vascular endothelial growth factor C; Vegfc; VEGF-C; Vascular endothelial growth factor-related protein; VRP; Flt4-L; FLT4 ligand DHM; Flt4 ligand
Gene ID: 114111
mRNA Refseq: NM_053653
Protein Refseq: NP_446105
UniProt ID: O35757
Chromosome Location: 16p11
Pathway: Bladder cancer; Cytokine-cytokine receptor interaction; Focal adhesion; Pancreatic cancer;Pathways in cancer; Renal cell carcinoma; mTOR signaling pathway
Function: growth factor activity; vascular endothelial growth factor receptor 3 binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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