Recombinant Human MAX Dimerization Protein 1

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Recombinant Human MAX Dimerization Protein 1

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Cat. No. : MXD1-2502H
Product Overview : Recombinant human MAD was expressed in anE. colisystem and purified by an affinity column in combination with FPLC chromatography. 24 kDa.
Description : MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with Myc for binding to MAX to form a sequence-specific DNA-binding complex, acting as a transcriptional repressor (while Myc appears to function as an activator) and is a candidate tumor suppressor. Both Myc and MAD, as well as the more recently described Mnt and Mga proteins, form heterodimers with MAX, permitting binding to specific DNA sequences. These DNA-bound heterodimers recruit coactivator or corepressor complexes that generate alterations in chromatin structure, which in turn modulate transcription. The wild-type c-Myc and c-Myc/MADBR proteins have indistinguishable biological activity and target gene recognition in vivo .
Source : E. coli.
Applications : MAD can be applied to DNA binding, proliferation, differentiation, and apoptosis research studies.
Activity : 1 unit equals 1 nanogram of purified protein.
Quality Control : The purified protein is greater than 95% homogeneous based on SDS-PAGE gel analysis.
Reagents Supplied : 1x dilution buffer A: 20 mM Tris-Cl (pH 8.0), 20% Glycerol, 100 mM KCl, 0.2 mM EDTA and 1mM DTT.
Storage Conditions : Store at -80°C.
PDB rendering based on 1nlw. :

Gene Name : MXD1 MAX dimerization protein 1 [ Homo sapiens ]
Synonyms : MAX dimerization protein 1; MAD; MAD1; MGC104659; MXD1; max dimerization protein 1; max dimerizer 1; OTTHUMP00000202211; MAD protein (MAX-binding protein); MAX dimerizer
Gene ID : 4084
mRNA Refseq : NM_002357
Protein Refseq : NP_002348
MIM : 600021
UniProt ID : Q05195
Chromosome Location : 2p13-p12
Function : protein binding; transcription cofactor activity; transcription corepressor activity; transcription factor activity

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