Active Recombinant Human STAT2, His-tagged
Cat.No. : | STAT2-2515H |
Product Overview : | Recombinant human His tagged STAT2 is expressed in abaculovirussystem and purified by affinity chromatography in combination with FPLC chromatography.110 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | STAT2-2515H |
Description : | Signal transducer and activator of transcription (STAT) proteins play a crucial role in the regulation of gene expression by mediating transcriptional responses to many cytokines and growth factors. The antiviral responses of IFN-α/β rely on the transcriptional activities of STAT1 and STAT2 proteins.The chromatin immunoprecipitation and DNA microarray analysis (Chip-chip) demonstrated that STAT2 (and STAT1) bound to chromosome 22 after IFN stimulation. STAT2 activity can be regulated by tyrosine phosphorylation that is catalyzed by a receptor associated JAK kinase. |
Source : | baculovirus. |
Applications : | Recombinant STAT2 (1-851) can be used for 1) in vitro transcription; 2) gel mobility shift assay and 3) for protein-protein interaction assay. |
Transcript Variant : | This variant represents the longer transcript and encodes the longer isoform. |
Activity : | 1 unit equals 1 nanogram of purified protein. |
Quality Control : | The purified protein is greater than 95% homogeneous and contains no detectable proteases, DNase and RNase activity. |
Reagents Supplied : | 1x dilution buffer A: 20 mM Tris-Cl (pH 8.0), 20% Glycerol, 100 mM KCl, 0.2 mM EDTA and 1mM DTT. |
Storage Conditions : | Store at -80°C. |
Pathways : | Chemokine signaling pathway; Jak-STAT signaling pathway |
Gene Name : | STAT2 signal transducer and activator of transcription 2, 113kDa [ Homo sapiens ] |
Synonyms : | STAT2; signal transducer and activator of transcription 2, 113kDa; P113; ISGF-3; STAT113; MGC59816; interferon alpha induced transcriptional activator; Signal transducer and activator of transcription 2; p113; signal transducer and activator of transcription 2, 113kD |
Gene ID : | 6773 |
mRNA Refseq : | NM_005419 |
Protein Refseq : | NP_005410 |
MIM : | 600556 |
UniProt ID : | P52630 |
Chromosome Location : | 12q13.3 |
Function : | calcium ion binding; hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity; protein binding; signal transducer activity; transcription factor activity |
Products Types
◆ Recombinant Protein | ||
STAT2-4333R | Recombinant Rhesus Macaque STAT2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Stat2-6169M | Recombinant Mouse Stat2 Protein, Myc/DDK-tagged | +Inquiry |
STAT2-4517R | Recombinant Rhesus monkey STAT2 Protein, His-tagged | +Inquiry |
Stat2-1809M | Recombinant Mouse Stat2 protein, His & T7-tagged | +Inquiry |
STAT2-2997H | Recombinant Human STAT2, GST-tagged | +Inquiry |
◆ Lysates | ||
STAT2-1419HCL | Recombinant Human STAT2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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