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Recombinant Human STAT2, His-tagged

Cat. No.: STAT2-2515H
Product Overview: Recombinant human His tagged STAT2 is expressed in abaculovirussystem and purified by affinity chromatography in combination with FPLC chromatography.110 kDa.
Description: Signal transducer and activator of transcription (STAT) proteins play a crucial role in the regulation of gene expression by mediating transcriptional responses to many cytokines and growth factors. The antiviral responses of IFN-α/β rely on the transcriptional activities of STAT1 and STAT2 proteins.The chromatin immunoprecipitation and DNA microarray analysis (Chip-chip) demonstrated that STAT2 (and STAT1) bound to chromosome 22 after IFN stimulation. STAT2 activity can be regulated by tyrosine phosphorylation that is catalyzed by a receptor associated JAK kinase.
Source: baculovirus.
Applications: Recombinant STAT2 (1-851) can be used for 1) in vitro transcription; 2) gel mobility shift assay and 3) for protein-protein interaction assay.
Transcript Variant: This variant represents the longer transcript and encodes the longer isoform.
Activity: 1 unit equals 1 nanogram of purified protein.
Quality Control: The purified protein is greater than 95% homogeneous and contains no detectable proteases, DNase and RNase activity.
Reagents Supplied: 1x dilution buffer A: 20 mM Tris-Cl (pH 8.0), 20% Glycerol, 100 mM KCl, 0.2 mM EDTA and 1mM DTT.
Storage Conditions: Store at -80°C.
Pathways: Chemokine signaling pathway; Jak-STAT signaling pathway
Gene Name: STAT2 signal transducer and activator of transcription 2, 113kDa [ Homo sapiens ]
Synonyms: STAT2; signal transducer and activator of transcription 2, 113kDa; P113; ISGF-3; STAT113; MGC59816; interferon alpha induced transcriptional activator; Signal transducer and activator of transcription 2; p113; signal transducer and activator of transcription 2, 113kD
Gene ID: 6773
mRNA Refseq: NM_005419
Protein Refseq: NP_005410
MIM: 600556
UniProt ID: P52630
Chromosome Location: 12q13.3
Function: calcium ion binding; hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity; protein binding; signal transducer activity; transcription factor activity

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