Recombinant Human Nerve Growth Factor (Beta Polypeptide)

• Cat.No.: NGF-28H

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Non
• Description: Beta-NGF, also known as nerve growth factor beta-1, NGF-b1, or NGF-beta, is a neurotrophic factor that influences the growth and differentiation of sympathetic and sensory neurons. Beta-NGF, comprised alpha, beta, and gamma subunits, is a 26 kDa non-covalently associated homodimer with 2 potential N-linked glycosylation sites.
• Analysis Note: The biological activity is measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1.
• Biochem/physiol Actions: NGF-β promotes the survival and cholinergic phenotype of basal forebrain cholinergic neurons and stimulates neurite outgrowth of embryonic trigeminal motor neurons in vitro.
• Physical Form: Lyophilized from 0.2% acetic acid containing 5 mg bovine serum albumin.
• Assay: >97% (SDS-PAGE).
• Form: lyophilized powder.
• Potency: 0.15-3.0 ng/mL ED50/EC50.
• Total Impurities: endotoxin, tested.
• Suitability: cell culture tested.
• Storage Temp: −20°C.

Gene Information

• Gene Name: NGF nerve growth factor (beta polypeptide) [ Homo sapiens ]
• Synonyms: NGF; nerve growth factor (beta polypeptide); NGFB; HSAN5; Beta-NGF; MGC161426; MGC161428; Beta-nerve growth factor; nerve growth factor, beta subunit; nerve growth factor, beta polypeptide; beta-nerve growth factor; OTTHUMP00000013653
• Gene ID: 4803
• mRNA Refseq: NM_002506
• Protein Refseq: NP_002497
• MIM: 162030
• UniProt ID: P01138
• Chromosome Location: 1p13.1
• Pathway: Apoptosis; MAPK signaling pathway; Neurotrophin signaling pathway; Signalling by NGF
• Function: growth factor activity; rve growth factor receptor binding; receptor signaling protein activity