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Recombinant Human TIMP Metallopeptidase Inhibitor 3

Cat.No. : TIMP3-2528H
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  • Gene Information
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Cat. No. : TIMP3-2528H
Description : Metalloproteinase inhibitor 3 is an enzyme that in humans is encoded by the TIMP3 gene. This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby"s fundus dystrophy.
Source : Mammalian cells
Analysis Note : The biological activity is measured by its ability to inhibit human MMP-2 hydrolysis of a peptide substrate.
Biochem/physiol Actions : The TIMPs are endogenous inhibitors of the matrix metalloproteinases (MMPs). TIMP-3 inhibits ADAM-17 (TACE) at nanomolar concentrations and also inhibits other metalloproteinases (sheddases) that mediate the shedding of soluble receptors and other proteins from the surface of cells.
Physical Form : Lyophilized from a 0.2 μm filtered solution in 25 mM Tris and 0.15 M sodium chloride, pH 7.5.
Assay : >95% (SDS-PAGE).
Form : buffered aqueous solution.
Mol Wt : apparent mol wt ~30 kDa.
Storage Temp : −20°C.
Gene Name : TIMP3 TIMP metallopeptidase inhibitor 3 [ Homo sapiens ]
Synonyms : TIMP metallopeptidase inhibitor 3; SFD; K222; K222TA2; HSMRK222; TIMP3; metalloproteinase inhibitor 3; TIMP-3; MIG-5 protein; protein MIG-5; tissue inhibitor of metalloproteinases 3; tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); Protein MIG-5; Tissue inhibitor of metalloproteinases 3
Gene ID : 7078
mRNA Refseq : NM_000362
Protein Refseq : NP_000353
MIM : 188826
UniProt ID : P35625
Chromosome Location : 22q12.1-q13.2; 22q12.3
Function : enzyme inhibitor activity; metal ion binding; metalloendopeptidase inhibitor activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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09/05/2019

    Manufacturers might offer customization options, such as different variants or modifications of the TIMP3 protein, to cater to specific research requirements.

    01/28/2018

      Such support helps researchers overcome challenges and obtain reliable results.

      06/06/2016

        This flexibility allows researchers to focus on specific aspects of TIMP3 protein functionality, regulation, or disease associations, enhancing the relevance and applicability of their work.

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