Recombinant Human TIE1, Fc Chimera
Cat.No. : |
TIE1-2531H |
Product Overview : |
Recombinant human TIE1 fused to Fc Chimera, was expressed inNSO. |
- Specification
- Gene Information
- Related Products
Cat. No. : |
TIE1-2531H |
Description : |
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (Tie-1) are novel endothelial cell tyrosine kinase receptors that are essential for vascular development and remodeling in the embryo. They are expressed almost exclusively in endothelial cells. Tie-1 also have a role in the regulatory pathways of early hematopoiesis and angiogenesis. It is upregulated in diseases such as atherosclerosis and rheumatoid arthritis. |
Source : |
Mammalian cells |
Biochem/physiol Actions : |
Tie (tyrosine kinase with Ig and EGF homology domains) receptors Tie-1 and Tie-2 are receptor tyrosine kinase (RTK) family members with unique structural characteristics that involve their two Ig-like, three EGF-like and three fibronectin III-like motifs in the extracellular domain. They also have a split tyrosine kinase domain in the cytoplasmic region. They are expressed primarily on endothelial cells and hematopoietic progenitors. Tie-1 and Tie-2 are thought to play critical roles in angiogenesis and hematopoiesis. Tie-1 is related to endothelial cell differentiation and maintenance of endothelium integrity. |
Physical Form : |
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline. |
Assay : |
≥90% (SDS-PAGE). |
Form : |
lyophilized powder. |
Total Impurities : |
endotoxin, tested. |
Suitability : |
cell culture tested. |
Storage Temp : |
−20°C. |
Gene Name : |
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 [ Homo sapiens ] |
Synonyms : |
TIE1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; soluble TIE1 variant 1; soluble TIE1 variant 2; soluble TIE1 variant 3; soluble TIE1 variant 4; soluble TIE1 variant 5; receptor tyrosine kinase; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; EC 2.7.10.1; JTK14; TIE; Tyrosine-protein kinase receptor Tie-1; OTTHUMP00000008352 |
Gene ID : |
7075 |
mRNA Refseq : |
NM_005424 |
Protein Refseq : |
NP_005415 |
MIM : |
600222 |
UniProt ID : |
P35590 |
Chromosome Location : |
1p34-p33 |
Function : |
ATP binding; nucleotide binding; protein binding; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity |
Products Types
Related Gene
TIE1
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