||Ecombinant Human Notch Homolog 3 produced inSf21 cellswas fused to Fc region of human.
||This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
||Calculated mol wt 71.4 kDa; mol wt 85-95 kDa by SDS-PAGE (reducing).
||Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
||The biological activity is measured by its ability to bind Jagged-1.