"MMP9" Related Products


Recombinant Human Matrix Metallopeptidase 9

Cat. No.: MMP9-709H
Product Overview: Recombinant human matrix metallopeptidase 9 was expressed inNSO Cells.
Description: Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. MMPs are synthesized as enzymogen and converted to active form by other MMPs or extracellular proteinases. MMP9, also known as 92-kDa gelatinase B/type IV collagenase, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. It contains a fibronectin-like domain, which functions in the binding of gelatin, a unique serine/proline/threonine-rich collagen type V-like domain probably serving as attachment sites of multiple O-linked oligosaccharides and a carboxyl terminal hemopexin-like domain. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin.
Source: NSO Cells.
Assay: >95% (SDS-PAGE).
Form: Buffered aqueous solution.
Mol wt: Apparent mol wt ~93 kDa.
Shipped In: Dry ice.
Storage Temp: −70℃.
Personal Protective Equipment: Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US)
Gene Name: MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) [ Homo sapiens ]
Synonyms: MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); GELB; CLG4B; MMP-9; MANDP2; MMP-9; EC; OTTHUMP00000031674; 92 kDa gelatinase 3; 92 kDa type IV collagenase; Gelatinase B; macrophage gelatinase 2; type V collagenase
Gene ID: 4318
mRNA Refseq: NM_004994
Protein Refseq: NP_004985
MIM: 120361
UniProt ID: P14780
Chromosome Location: 20q12-q13
Pathway: Bladder cancer; Pathways in cancer; Leukocyte transendothelial migration
Function: calcium ion binding; collagen binding; metalloendopeptidase activity; peptidase activity; zinc ion binding

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