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Recombinant Human PCSK9, His-tagged

Cat.No. : PCSK9-643H
Product Overview : Recombinant Human PCSK9(Met 1-Gln 692) fussed with His tag at C-terminal was expressed in Wheat Germ.
Description : PCSK9 is a circulating glycosylated serine protease expressed primarily in kidney, liver, cerebellum, and small intestine. In order for secretion to occur, PCSK9 cleaves its own prodomain, which remains associated and largely inhibits further proteolytic activity. The major function of PCSK9 appears to be regulation of circulating cholesterol levels through its binding of the LDL receptor, resulting in degradation of the LDLR. siRNA inhibition of PCSK9 expression lowers plasma PCSK9, apoB, and LDL cholesterol. PCSK9 may also be involved in Alzheimer’s disease due to its requirement for degradation of BACE1.
Source : Human Cells
Species : Human
Tag : His
Form : Lyophilized from a 0.2µm filtered solution of PBS, pH 7.4, containing 8% trehalose, 8% mannitol.
Bio-activity : Measure by its ability to bind with human LDLR in a functional ELISA: Immobilized recombinant human PCSK9 at 10µg/ml (100µl/well) can bind biotinylated human LDLR. The EC50 of biotinylated human LDLR is 0.61µg/ml.
Molecular Mass : 72.6 kDa (predicted). Migrates as a doublet of 20kDa (pro domain) and 62kDa (mature form) in SDS-PAGE under reducing conditions.
Endotoxin : <1.0 EU per µg protein (LAL test)
Purity : ≥97% (SDS-PAGE)
Notes : Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Storage : Short Term Storage: -80°C
Gene Name : PCSK9 proprotein convertase subtilisin/kexin type 9 [ Homo sapiens ]
Official Symbol : PCSK9
Synonyms : FH3; PC9; NARC1; LDLCQ1; NARC-1; HCHOLA3; proprotein convertase subtilisin/kexin type 9; convertase subtilisin/kexin type 9 preproprotein; neural apoptosis regulated convertase 1; subtilisin/kexin-like protease PC9
Gene ID : 255738
mRNA Refseq : NM_174936
Protein Refseq : NP_777596
MIM : 607786
UniProt ID : Q8NBP7
Chromosome Location : 1p32.3
Function : apolipoprotein binding; apolipoprotein receptor binding; low-density lipoprotein particle binding

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