Human CCL19 CCL19-110H

September 27-30, 2022

Boston Convention and Exhibition Center

Booth #336

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Human CCL19

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Cat.No. : CCL19-110H Optional Service: Optional requirements on this protein
Product Overview : It is a synthetic Protein
Description : MIP-3b is related to other b chemokines, possessing 20-30% sequence identity with other b proteins. MIP-3b has been mapped to the 9p13 chromosome. This differs from other b proteins which are mapped to chromosome 17. MIP-3b is expressed in a variety of lymphoid tissues. and is down-regulated by the anti-inflammatory cytokine IL-10. Synthetic MIP-3b is chemotactic for cultured human lymphocytes and is a unique functional ligand for CCR-7. The CCR-7 receptor has been previously referred to as the Epstein-Barr virus-induced gene 1 (EBI1). CCR-7 is a chemokine receptor which is expressed in various lymphoid tissues and activated B and T lymphocytes. EBI1 is strongly up-regulated in B cells infected with Epstein-Barr virus and T cells infected with herpesvirus 6 or 7.
Species : Human
Form : Lyophilized
Bio-activity : Activity measured by the protein's ability to chemoattract cultured human lymphocytes. ED50 for this activity is between 0.1 and 0.4 μg/ml
AA Sequence : GTNDAEDCCL SVTQKPIPGY IVRNFHYLLI KDGCRVPAVV FTTLRGRQLC APPDQPWVER IIQRLQRTSA KMKRRSS
Applications : Activity Assay
Storage : Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Reconstitution : Recommended reconstitution in sterile phosphate buffered saline which contains at least 0.1% human or bovine serum albumin to prepare a stocksolution of no less than 20 μg/ml and vortex thoroughly.
Gene Name : CCL19 chemokine (C-C motif) ligand 19 [ Homo sapiens ]
Official Symbol : CCL19
Synonyms : CCL19; chemokine (C-C motif) ligand 19; SCYA19, small inducible cytokine subfamily A (Cys Cys), member 19; C-C motif chemokine 19; beta chemokine exodus 3; CC chemokine ligand 19; CK beta 11; CKb11; EBI1 ligand chemokine; ELC; exodus 3; macrophage inflammatory protein 3 beta; MIP 3b; exodus-3; CK beta-11; MIP-3-beta; EBI1-ligand chemokine; beta chemokine exodus-3; beta-chemokine exodus-3; small-inducible cytokine A19; macrophage inflammatory protein 3-beta; epstein-Barr virus-induced molecule 1 ligand chemokine; small inducible cytokine subfamily A (Cys-Cys), member 19; MIP3B; MIP-3b; SCYA19; MGC34433;
Gene ID : 6363
mRNA Refseq : NM_006274
Protein Refseq : NP_006265
MIM : 602227
UniProt ID : Q99731
Chromosome Location : 9p13
Pathway : Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem;
Function : CCR chemokine receptor binding; CCR10 chemokine receptor binding; CCR7 chemokine receptor binding; chemokine activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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