Human CYFIP1 Knockdown Cell Lysate

• Cat.No.: CYFIP1-132HKCL
• Product Overview: WB-validated CYFIP1 Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization. This protein also interacts with the synaptic functional regulator FMR1 protein and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 145 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg CYFIP1 KD HeLa cell lysate
• Protein Pathways: Regulation of actin cytoskeleton
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: CYFIP1 cytoplasmic FMR1 interacting protein 1 [ Homo sapiens (human) ]
• Official Symbol: CYFIP1
• Synonyms: CYFIP1; cytoplasmic FMR1 interacting protein 1; cytoplasmic FMR1-interacting protein 1; cytoplasmic FMRP interacting protein 1; KIAA0068; P140SRA 1; selective hybridizing clone; SHYC; sra-1; specifically Rac1-associated protein 1; SRA1; P140SRA-1; FLJ45151
• Gene ID: 23191
• mRNA Refseq: NM_001033028
• Protein Refseq: NP_001028200
• MIM: 606322
• UniProt ID: Q7L576