Human LMAN1 Knockdown Cell Lysate

• Cat.No.: LMAN1-227HKCL
• Product Overview: WB-validated LMAN1 Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 58 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg LMAN1 KD HeLa cell lysate
• Protein Families: Druggable Genome, Transmembrane
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: LMAN1 lectin, mannose-binding, 1 [ Homo sapiens (human) ]
• Official Symbol: LMAN1
• Synonyms: LMAN1; lectin, mannose-binding, 1; coagulation factor V factor VIII combined deficiency, F5F8D; protein ERGIC-53; endoplasmic reticulum golgi intermediate compartment protein 53; ERGIC 53; ERGIC53; FMFD1; gp58; MCFD1; MR60; intracellular mannose specific lectin; intracellular mannose-specific lectin MR60; ER-Golgi intermediate compartment 53 kDa protein; endoplasmic reticulum-golgi intermediate compartment protein 53; F5F8D; ERGIC-53
• Gene ID: 3998
• mRNA Refseq: NM_005570
• Protein Refseq: NP_005561
• MIM: 601567
• UniProt ID: P49257