Native Bovine Calmodulin

• Cat.No.: CALM3-74B

Specification

• Description: Calmodulin (CaM) is a ubiquitous, calcium-binding protein that can bind to and regulate a multitude of different protein targets, thereby affecting many different cellular functions. CaM mediates processes such as inflammation, metabolism, apoptosis, muscle contraction, intracellular movement, short-term and long-term memory, nerve growth and the immune response. CaM is expressed in many cell types and can have different subcellular locations, including the cytoplasm, within organelles, or associated with the plasma or organelle membranes. Many of the proteins that CaM binds are unable to bind calcium themselves, and as such use CaM as a calcium sensor and signal transducer. CaM can also make use of the calcium stores in the endoplasmic reticulum, and the sarcoplasmic reticulum. CaM undergoes a conformational change upon binding to calcium, which enables it to bind to specific proteins for a specific response. CaM can bind up to four calcium ions, and can undergo post-translational modifications, such as phosphorylation, acetylation, methylation and proteolytic cleavage, each of which can potentially modulate its actions.
• Source: Bovine Brain
• Species: Bovine
• Form: Lyophilized
• Molecular Mass: 16 kDa
• Purity: Purity by SDS-PAGE: ≥95%
• Usage: For Research Use Only! Not For Use in Humans.
• Notes: Centrifuge the vial prior to opening
• Storage: -20°C
• Storage Buffer: Lyophilized in 30 mM Hepes, pH 7.4, 1 mM CaCl2 and 0.1 mM DTT.
• Reconstitution: In water or aqueous buffer
• Shipping: Gel pack

Gene Information

• Gene Name: CALM3 calmodulin 3 (phosphorylase kinase, delta) [ Bos taurus ]
• Official Symbol: CALM3
• Synonyms: calmodulin
• Gene ID: 520277
• mRNA Refseq: NM_001046249
• Protein Refseq: NP_001039714
• UniProt ID: P62157
• Chromosome Location: chromosome: 18
• Pathway: Activation of Ca-permeable Kainate Receptor, organism-specific biosystem; Activation of Kainate Receptors upon glutamate binding, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem