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Native Human CA6

Cat.No. : CA6-804H
Product Overview : Native Human CA6 was isolated from human milk.
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Description : Carbonic anhydrases (CAs) are enzymes which catalyze the reversible hydration of carbon dioxide according to the following reaction: CO2 + H2O ↔ HCO3- + H+. The main function of this protein family is to regulate the acid-base balance, which is of a considerable biological importance. In addition, they participate in several other physiological functions including CO2 and HCO3- transport, bone resorption, production of biological fluids, ureagenesis, gluconeogenesis and lipogenesis. Carbonic anhydrases are metalloenzymes containing a zinc-atom in their active site. The expanding CA gene family includes at least 13 enzymatically active members with different structural and catalytic properties.
Purified by CA inhibitor affinity chromatography.
Source : Human milk
Species : Human
Form : 0.1 M Tris-SO4 pH 7.0, 0.4 M NaN3, 1 mM Benzamidine and 20 % glycerol, pH 7.0
Molecular Mass : 35 kDa
AASequence : MRALVLLLSLFLLGGQAQHVSDWTY SEGALDEAHWPQHYPACGGQRQSPI NLQRTKVRYNPSLKGLNMTGYETQA GEFPMVNNGHTVQISLPSTMRMTVA DGTVYIAQQMHFHWGGASSEISGSE HTVDGIRHVIEIHIVHYNSKYKSYD IAQDAPDGLAVLAAFVEVNYPENTY YSNFISHLANIKYPGQRTTLTGLDV QDMLPRNLQHYYTYHGSLTTPPCTE NVHWFVLADFVKLSRTQVWKLENSL LDHRNKTIHNDYRRTQPLNHRVVES NFPNQEYTLGSEFQFYLHKIEEILD YLRRALN
Purity : > 95 % (SDS-PAGE under reducing conditions)
Storage : Store at -80 centigrade, avoid freeze/thaw cycles.
Gene Name : CA6 carbonic anhydrase VI [ Homo sapiens ]
Official Symbol : CA6
Synonyms : CA-VI; GUSTIN
Gene ID : 765
mRNA Refseq : NM_001215.3
Protein Refseq : NP_001206.2
MIM : 114780
UniProt ID : P23280

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there known genetic mutations in the CA6 gene, and how do they influence protein function? 04/05/2021

Genetic variations might affect CA6's secretion or activity, necessitating functional assays for evaluation.

What is the primary physiological function of CA6? 02/04/2021

CA6 plays a role in the reversible conversion of CO2 to bicarbonate and protons, aiding in pH balance and CO2 transport.

Are there any known proteins or molecules that interact directly with CA6? 05/27/2020

Direct interaction partners for CA6 require further investigation, but it may have specific binding properties due to its unique location.

Where is CA6 predominantly located within the human body? 04/09/2020

CA6 is mainly secreted in saliva and is found in salivary glands.

What are the post-translational modifications identified on CA6? 12/21/2019

Specific post-translational modifications on CA6 can be explored through techniques like mass spectrometry.

How does the enzymatic activity of CA6 compare to other carbonic anhydrase isoforms? 03/31/2018

CA6's activity might be tailored for salivary pH regulation, potentially differing in kinetics from other isoforms.

Are there specific pathological conditions linked with CA6 dysregulation? 06/24/2017

Dysregulation of CA6 might influence oral health, pH regulation, or conditions affecting the salivary glands.

Customer Reviews (3)

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Reviews
12/15/2021

    Outstanding purification techniques, yield top-notch samples.

    09/26/2021

      Fast turnaround time, meets our project deadlines efficiently.

      07/01/2021

        Efficient sample handling, simplifies our daily workloads.

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