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Native Human GC protein

Cat.No. : GC-524H
Product Overview : Native Human GC Globulin(Vitamin D Binding Protein) was purified from Human Plasma.
  • Specification
  • Gene Information
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Description : An alpha 2 glycoprotein composed of a single polypeptide chain and present in plasma at levels of 20-55 mg/100 ml. It functions in the binding and transport of vitamin D and may also play an important role in actin homeostatis since it has been shown to bind monomeric actin with high affinity. GC-globulin also binds membranes of both circulating B and T lymphocytes. Clinically, concentrations are reduced in patients with severe liver diseases. GC-globulin may also play an important role in the mechanism of the osteomalacia that occurs with Itai-Itai disease.
Source : Human Plasma
Species : Human
Form : Lyophilized from 20 mM Na phosphate, pH 7.4, with 150 mM NaCl.
Molecular Mass : 56000
Purity : >=95% by SDS-PAGE
Gene Name : GC group-specific component (vitamin D binding protein) [ Homo sapiens ]
Official Symbol : GC
Synonyms : GC; group-specific component (vitamin D binding protein); vitamin D-binding protein; DBP; hDBP; VDBP; VDB; gc-globulin; vitamin D-binding alpha-globulin; GRD3; VDBG; DBP/GC;
Gene ID : 2638
mRNA Refseq : NM_000583
Protein Refseq : NP_000574
MIM : 139200
UniProt ID : P02774
Chromosome Location : 4q12-q13
Pathway : Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Metabolism of steroid hormones and vitamins A and D, organism-specific biosystem; Vitamin D (calciferol) metabolism, organism-specific biosystem;
Function : actin binding; vitamin D binding; vitamin transporter activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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