Native Mouse Hspg2 Protein

• Cat.No.: Hspg2-017M
• Product Overview: Isolated from basement membrane of Engelbreth-Holm-Swarm mouse sarcoma. Content: 400 μg/mL (protein) 400 μg/mL (glycosaminoglycan) 100 μg/mL (uronic acid)

Specification

• Species: Mouse
• Description: Enables protease binding activity. Involved in receptor-mediated endocytosis. Acts upstream of or within several processes, including cardiac muscle tissue development; extracellular matrix organization; and skeletal system development. Located in basement membrane. Is expressed in several structures, including alimentary system; cardiovascular system; early conceptus; genitourinary system; and nervous system. Used to study Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; dextro-looped transposition of the great arteries; and thanatophoric dysplasia. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2).
• Molecular Mass: ≥400 kDa
• Applications: For cell culture use.
• Storage: At -20 centigrade.
• Concentration: ≥400 μg/mL glycosaminoglycan
• Shipping: Dry Ice
• Storage Buffer: 50 mM Tris HCl, 150 mM NaCl, 1 mM EDTA, 0.1 mM PMSF, pH 7.4
• Contaminants: ≥100 μg/mL Uronic acid
• Specific binding: Peptide Source: Collagen Type IV Peptide Source: Fibronectin Peptide Source: Laminin

Gene Information

• Gene Name: Hspg2 perlecan (heparan sulfate proteoglycan 2) [ Mus musculus (house mouse) ]
• Official Symbol: Hspg2
• Synonyms: Hspg2; perlecan (heparan sulfate proteoglycan 2); HSPG; glycosaminoglycan; Pcn; Plc; per; HSPG; basement membrane-specific heparan sulfate proteoglycan core protein
• Gene ID: 15530
• mRNA Refseq: NM_008305
• Protein Refseq: NP_032331
• UniProt ID: Q05793