Recombinant Active Human IL17B Protein, His-tagged(C-ter)
Cat.No. : | IL17B-150H |
Product Overview : | Recombinant Active Human IL17B Protein with His tag (C-ter) was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. [provided by RefSeq, Jul 2008] |
Source : | E. coli |
Species : | Human |
Tag : | His(C-ter) |
Form : | Powder |
Bio-activity : | Determined by its ability to induce IL-8 secretion in human PBMCs. The ED50 for this effect is < 49 ng/mL. |
AA Sequence : | MQPRSPKSKRKGQGRPGPLAPGPHQ VPLDLVSRMKPYARMEEYERNIEEM VAQLRNSSELAQRKCEVNLQLWMSN KRSLSPWGYSINHDPSRIPVDLPEA RCLCLGCVNPFTMQEDRSMVSVPVF SQVPVRRRLCPPPPRTGPCRQRAVM ETIAVGCTCIF |
Endotoxin : | Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test. |
Purity : | > 98% (by SDS-PAGE) |
Applications : | SDS-PAGE |
Notes : | For laboratory research only, not for drug, diagnostic or other use. |
Storage : | Lyophilized protein should be stored at -20°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
Storage Buffer : | PBS (pH 8.0) |
Reconstitution : | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
Gene Name : | IL17B interleukin 17B [ Homo sapiens ] |
Official Symbol : | IL17B |
Synonyms : | IL17B; interleukin 17B; interleukin-17B; IL 17B; IL 20; MGC138900; MGC138901; neuronal interleukin 17 related factor; NIRF; ZCYTO7; interleukin 20; interleukin-20; cytokine Zcyto7; interleukin-17 beta; cytokine-like protein ZCYTO7; neuronal interleukin-17 related factor; neuronal interleukin-17-related factor; IL-20; IL-17B; |
Gene ID : | 27190 |
mRNA Refseq : | NM_014443 |
Protein Refseq : | NP_055258 |
MIM : | 604627 |
UniProt ID : | Q9UHF5 |
Products Types
◆ Lysates | ||
IL17B-5244HCL | Recombinant Human IL17B 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionCo-culture experiments and signaling pathway analysis reveal IL17B's interaction with other cytokines.
Techniques like surface plasmon resonance elucidate IL17B's binding to its receptor.
In vivo models combine IL17B overexpression or neutralization with tumor models to study its role.
Human tissue samples are analyzed using immunohistochemistry and cytokine profiling to understand IL17B's effects.
Flow cytometry and functional assays explore how IL17B affects immune cell activation and cytokine production.
Research uses animal models and biomarker analysis to study IL17B in neuroinflammatory diseases.
Genetic techniques like CRISPR/Cas9 knockout or siRNA knockdown validate IL17B's functional impact.
Transwell assays and impedance-based methods evaluate IL17B's impact on endothelial barrier integrity.
Western blotting and phosphorylation assays uncover IL17B's downstream signaling pathways.
Gene expression analysis involves qPCR or RNA sequencing to distinguish IL17B expression patterns.
Customer Reviews (3)
Write a reviewSuitable for signaling studies.
High solubility
Potent in B-cell assays.
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