| Description : |
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011] |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
Tag Free |
| Form : |
Powder |
| Bio-activity : |
Determined by its ability to stimulate the proliferation of mouse B9 cells. |
| AA Sequence : |
PVPPGEDSKDVAAPHRQPLTSSERI DKQIRYILDGISALRKETCNKSNMC ESSKEALAENNLNLPKMAEKDGCFQ SGFNEETCLVKIITGLLEFEVYLEY LQNRFESSEEQARAVQMSTKVLIQF LQKKAKNLDAITTPDPTTNASLLTK LQAQNQWLQDMTTHLILRSFKEFLQ SSLRALRQM |
| Purity : |
> 98% by SDS-PAGE gel and HPLC analyses. |
| Applications : |
FuncSt, SDS-PAGE |
| Notes : |
For laboratory research only, not for drug, diagnostic or other use. |
| Storage : |
Lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
