Recombinant Anti-Human RANKL Monoclonal Antibody

• Cat.No.: CABT-P1009H
• Product Overview: Recombinant monoclonal antibody to Human RANKL.

Specification

• Species: Human
• Tag: Non
• Antigen Description: Cytokine that binds to TNFRSF11B/OPG and toTNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augmentsthe ability of dendritic cells to stimulate naive T-cell proliferation. Maybe an important regulator of interactions between T-cells and dendritic cellsand may play a role in the regulation of the T-cell-dependent immuneresponse. May also play an important role in enhanced bone-resorption inhumoral hypercalcemia of malignancy.
• Protein Costruction: DNAsequences coding OPGL antibody heavy and light chains cotransfected to hostcell were expressed with a human Igκ signal in light chain.
• Isotype: IgG2
• Formulation: Normally 1mg/mlL-His, 1mg/ml Sucrose and 0.04 mg/ml Tween-80 are added, pH 6.0. Pleasecontact us for any concerns or special requirements.
• Purity Detail: >95% asdetermined by SDS-PAGE and HPLC
• Expression Host: Chinese HamsterOvary (CHO cell)
• Endotoxin: <1.0EUper 10 mg protein as determined by the LAL method
• Molecular Mass: The secreted recombinant Monoclonal antibody to human RANKL comprises 1326 amino acids. As a result ofglycosylation, it has molecular mass of 150kDa in SDS-PAGE under non-reducingconditions.
• Predicted N terminal: Hchain: EVQLLESGGG;Lchain:EIVLTQSPGT
• Stability: Samples are stablefor up to twelve months from date of receipt at -20°C and are stable forsix months at 4°C.
• Storage: Store it understerile conditions at -70°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
• Background: The monoclonal antibody to RANKL is a human IgG2 monoclonal antibody, have affinity andspecificity with human RANKL (receptor activator of nuclear factor kappa-Bligand). 147 kDa Molecular weight, is genetically engineered mammalian(Chinese hamster ovary) cell production.

Gene Information

• Gene Name: TNFSF11 tumor necrosisfactor (ligand) superfamily, member 11 [ Homo sapiens ]
• Official Symbol: TNFSF11
• Synonyms: ODF; OPGL; sOdf; CD254; OPTB2; RANKL;TRANCE; hRANKL2 ; Osteoclast differentiation factorantibody; Osteoprotegerin ligand antibody; Receptor activator of nuclearfactor kappa B ligand; Receptor activator of nuclear factor kappa-B ligand;sOdf antibody; SOFA antibodyTNF related activation induced cytokineantibody; TNF11_HUMAN; TNFSF 11 antibody; TRANCE; Tumor necrosis factor(ligand) superfamily member 11; Tumor necrosis factor ligand superfamilymember 11; soluble form antibody interleukin-12 subunit beta; interleukin-12 subunit beta
• Gene ID: 8600
• mRNA Refseq: NM_003701.3
• Protein Refseq: NP_003692.1
• MIM: 602642
• UniProt ID: Q5T9Y4
• Chromosome Location: 13q14
• Pathway: Cytokine-cytokine receptor interaction; Cytokine-cytokinereceptor interaction; IL6-mediated signaling events; Osteoblast Signaling; Osteoclastdifferentiation; Rheumatoid arthritis
• Function: cytokine activity; receptoractivity; tumor necrosis factor receptor binding; tumor necrosis factorreceptor superfamily binding