Recombinant Bat SARS-like coronavirus/HKU3-1 S(1-1190) protein
|Product Overview :||Purified recombinant Bat SARS-like coronavirus/HKU3-1 S(1-1190) protein was expressed in HEK293 cells.|
Spike protein S1: Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.
Spike protein S2: Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
|Species :||Bat SARS-like-CoV|
|Form :||Each vial contains 100 ug purified protein (1mg/ml) in PBS (pH7.4).|
|Applications :||WB standard, Ab ELISA, immunogen, etc.|
|Usage :||For research use only, not for use in diagnostic procedures.|
|Storage :||Store at -80 centigrade, Avoid freeze/thaw cycle.|
|Concentration :||1 mg/ml|
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