Recombinant Bovine Prion Protein (F209S), His-tagged
Cat.No. : | Prnp-801B |
Product Overview : | Recombinant Bovine Prion Protein (F209S) was expressed in E. coli with His tag. |
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- Gene Information
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Description : | N-terminal His-tagged mutant (F209S) mature PrPc. The protein may be reconstituted in detergent-containing buffers e.g. TX-100 (0.5%) or under mild denaturing conditions (e.g. 1.5 M guanidine-HCl or urea). The bovine PrPc (F209S) is a homologue to the disease-associated human (F198S) point mutation. It may be used to investigate the effect of this mutation for protein stability in in vitro/in vivo conversion studies. |
Source : | E. coli |
Species : | Bovine |
Tag : | His |
Form : | Lyophilized from 10 mM Tris-HCl pH 6.7 |
Purity : | > 95 % (SDS-PAGE) |
Storage : | Store at -80 centigrade, avoid freeze/thaw cycles. |
Gene Name : | PRNP prion protein [ Bos taurus (cattle) ] |
Official Symbol : | Prnp |
Synonyms : | PrP; AltPrP |
Gene ID : | 281427 |
mRNA Refseq : | AB001468.1 |
Protein Refseq : | ABE02802.1 |
UniProt ID : | P10279 |
Products Types
◆ Recombinant Protein | ||
PRP-01C | Recombinant Cervid PRNP Protein, His-tagged | +Inquiry |
PRNP-4367R | Recombinant Rat PRNP Protein, His (Fc)-Avi-tagged | +Inquiry |
PRNP-555C | Recombinant Cynomolgus Monkey PRNP Protein, His (Fc)-Avi-tagged | +Inquiry |
PRNP-3435R | Recombinant Rhesus Macaque PRNP Protein, His (Fc)-Avi-tagged | +Inquiry |
PRNP-742R | Recombinant Rat PRNP Protein (29-231 aa), His-tagged | +Inquiry |
◆ Lysates | ||
PRNP-001HCL | Recombinant Human PRNP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionRegulating the expression level of PRNP can influence the development of neurodegenerative diseases and the treatment effect. For example, certain drugs can inhibit the death of neurons and slow the progression of the disease by inhibiting the expression level of PRNP.
PRNP has some association with other biomarkers. For example, in Creutzkok disease, abnormal folding and aggregation of PRNP proteins can be used with biomarkers such as amyloid to assess the diagnosis and prognosis of the disease.
PRNP expression levels can be used to aid in diagnosing neurodegenerative diseases and assessing prognosis. For example, in Alzheimer's disease, detecting mutations in the PRNP gene can predict disease development and prognosis.
It can be used to aid in diagnosing neurological diseases and assessing prognosis by detecting mutations and expression levels of the PRNP gene. For example, in Creutzkok disease, detecting mutations in the PRNP gene can predict the diagnosis and prognosis of the disease.
The expression level of PRNP is associated with the occurrence and progression of neurodegenerative diseases. For example, in Alzheimer's disease and Parkinson's disease, PRNP expression levels can change and may contribute to the development of the disease.
Mutations or abnormal expression of PRNP may be associated with a variety of neurological disorders. For example, in Creutzkok disease, mutations in the PRNP gene lead to abnormal protein folding and aggregation, which in turn causes the disease. In addition, in diseases such as Alzheimer's disease and Parkinson's disease, PRNP expression levels may also change and promote the development of the disease.
Customer Reviews (3)
Write a reviewPRNP showed good solubility in Western blot and could be easily dissolved in various buffers.
The stability of PRNP was still very good under different environmental conditions, indicating its wide applicability and stability.
Using PRNP for experiments, I can perform experimental manipulations more easily without having to worry about the reproducibility of experimental results.
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