Recombinant Canine CTLA4 Protein, Fc-tagged, Alexa Fluor 488 conjugated
Cat.No. : | CTLA4-1060CAF488 |
Product Overview : | Alexa Fluor 488 conjugated recombinant canine CD152 (NP_001003106.1) (Met1-Asp161) was expressed with the Fc region of human IgG1 at the C-terminus. |
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- Gene Information
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Source : | HEK293 |
Species : | Dog |
Tag : | Fc |
Form : | Lyophilized |
Molecular Mass : | 40.1 kDa |
Protein length : | 364 |
N-terminal Sequence Analysis : | Lys 36 |
Endotoxin : | < 1.0 EU/ μg of the protein as determined by the LAL method. |
Purity : | > 90 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 488 via amines Excitation Wavelength: 488 nm Emission Wavelength: 515-545 nm |
Stability : | Samples are stable for up to 12 months from date of receipt at -70 centigrade. |
Storage : | Store it under sterile conditions at -20 to-70 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4, 5%-8% trehalose and mannitol. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Canis lupus familiaris ] |
Official Symbol : | CTLA4 |
Synonyms : | CD152; CTLA-4; costimulatory molecule B7 receptor CD152; cytotoxic T-lymphocyte-associated antigen 4 |
Gene ID : | 403696 |
mRNA Refseq : | NM_001003106 |
Protein Refseq : | NP_001003106 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, several clinical trials are investigating the combination of CTLA-4 inhibitors with PD-1 inhibitors and other immunotherapies to improve the overall effectiveness of cancer treatment.
CTLA-4 is expressed on various immune cells, including T cells, regulatory T cells (Tregs), and some B cells, contributing to its diverse immunoregulatory functions.
Modulating CTLA-4 may have applications in organ transplantation by suppressing the immune response against transplanted tissues and reducing the risk of rejection.
CTLA-4 is involved in the suppression of autoreactive T cells, contributing to the prevention of autoimmune responses by maintaining immune tolerance.
While both CTLA-4 and PD-1/PD-L1 inhibitors enhance anti-tumor immune responses, they target different checkpoints in the immune system. CTLA-4 primarily regulates T-cell activation in the early stages, whereas PD-1/PD-L1 acts later in the immune response.
Customer Reviews (3)
Write a reviewIt has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.
The CTLA4 protein is a top-quality product that is sure to fulfill my experimental requirements.
the ease of use and compatibility of the CTLA4 protein with various techniques further enhances its appeal.
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