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Recombinant Canine IL2RB Protein, His-tagged

Cat.No. : IL2RB-453C
Product Overview : Recombinant Canine IL2RB (NP_001273779.1) (Met1-Pro244) was expressed with a polyhistidine tag at the C-terminus.
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Description : Interleukin-2 receptor (IL-2R) also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated end centigradeytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymph centigradeytes, activated B lymph centigradeytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymph centigradeyte development.
Source : HEK293
Species : Canine
Tag : His
Predicted N Terminal : Ser 25
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 %- 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant canine IL2RB consists of 231 amino acids and predicts a molecular mass of 26.8 kDa.
Protein length : Met1-Pro244
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 95 % as determined by SDS-PAGE.
Storage : Samples are stable for up to twelve months from date of receipt at-70 centigrade. Store it under sterile conditions at-20 centigrade to-80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Official Symbol : IL2RB
Synonyms : IL2RB;interleukin 2 receptor subunit beta;interleukin-2 receptor subunit beta;IL 2/15 receptor beta chain;interleukin 2 receptor, beta
Official Symbol : IL2RB
Synonyms : IL2RB;interleukin 2 receptor subunit beta;interleukin-2 receptor subunit beta;IL 2/15 receptor beta chain;interleukin 2 receptor, beta

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is IL2RB and what are its clinical applications? 09/18/2022

It is an artificial protein prepared by genetic engineering techniques that can mimic the natural IL-2R beta subunit and is used to explore how to treat cancer and autoimmune diseases by regulating the IL-2 signaling pathway.

What is the effect of IL2RB in the treatment of tumor? 05/27/2022

There has shown good therapeutic effect in the treatment of some tumors (such as lung cancer, melanoma, etc.), but the specific efficacy varies with the patient's condition, treatment timing and other factors.

What is the therapeutic mechanism of IL2RB in clinical use? 12/13/2021

This protein can simulate the natural IL-2R beta subunit and participate in the IL-2 signaling pathway, thereby enhancing the body's immunity.

What diseases is IL2RB associated with? 06/07/2021

IL2RB is associated with a variety of cancers (such as gastric cancer, lung cancer, liver cancer, lymphoma, etc.) and autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus, etc.).

Can IL2RB be an alternative to traditional treatment? 04/10/2020

IL2RB can be used as a new therapeutic method, but it does not mean that it can replace traditional therapeutic methods. In the course of specific treatment, different treatment methods should be considered according to the condition.

Does IL2RB have side effects? 06/22/2019

IL2RB may produce some side effects, including fever, headache, nausea, vomiting, etc., but the incidence of different side effects is low.

Customer Reviews (3)

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Reviews
09/07/2021

    Immunogenicity is very weak and does not cause an immune response.

    12/27/2019

      Detection method is very sensitive and can detect trace amounts of protein.

      08/15/2019

        Preparation process is very simple and can be easily prepared.

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