| Description : |
Classical swine fever (CSF) remains one of the most economically significant viral diseases affecting domestic and wild pigs globally. The causative agent, the Classical Swine Fever Virus (CSFV), is highly contagious, with a high rate of morbidity and mortality. CSFV is an enveloped, positive-sense single-stranded RNA virus. Its genome, approximately 12.3 kb in length, encodes a single polyprotein precursor consisting of 3,898 amino acids. This precursor is processed by both host and viral proteases into mature structural and non-structural proteins. The structural proteins include the nucleocapsid protein C and three envelope glycoproteins: E0 (Erns), E1, and E2. In the viral envelope and infected cells, CSFV glycoproteins exist as biologically active disulfide-linked homodimers and heterodimers. Among them, E2 is the most immunogenic and serves as the primary target for neutralizing antibodies. Erns is the second target for neutralizing antibodies, existing as a homodimer with a molecular weight of approximately 97 kDa in viral particles, on the surface of infected cells, and is also secreted by cells. |
| Advantages : |
High Protein Purity: CFSV E2 Protein boasts a purity level exceeding 95%, ensuring a high-quality and consistent protein preparation.
Superior Stability and Immunogenicity: The protein demonstrates outstanding stability, with minimal degradation even after four months of storage at 4 centigrade. Its biological activity and immunogenicity are closely aligned with those of natural protein molecules.
Robust Immunization: The product induces a strong immune response, with all experimental pigs developing positive antibodies against swine fever.
Elevated Antibody Titers: The antibody levels generated by this product surpass those of comparable E2 vaccines on the market, providing extended immune protection for up to 6 months.
Extended Storage Capability: With excellent stability and negligible degradation after four months at 4 centigrade, the product is well-suited for long-term storage, maintaining its efficacy over extended periods. |
