Active Recombinant Cynomolgus CYP2C9 Protein
Cat.No. : | CYP2C9-125C |
Product Overview : | Recombinant cynomolgus CYP2C9 protein and human CYP-reductase without tag were coexpressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | CYP2C9 mediated oxidation of valproate, which is the minor metabolic pathway in adults, appears to become the principal route in children. Genetic and non-genetic variations in CYP2C9 activity can result in significant inter- and intra-individual differences in valproate pharmacokinetics and valproate induced adverse reactions. |
Source : | E. coli |
Species : | Cynomolgus |
Bio-activity : | Cytochrome c Reductase Activity: 191 nmol/min/mg protein P450 Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 50 mM potassium phosphate buffer (pH 7.4) containing 5 mM magnesium chloride and an NADPH generating system [5 mM glucose 6-phosphate, 1 mM NADP+, 1 U/ml glucose 6-phosphate dehydrogenase]) Activity: Testosterone 17-oxidase Linear with time up to: 30 min(Determined at 15 µM substrate, using a P450 concentration of 10 pmol/ml) Linear with P450 up to: 50 pmol/ml(Determined at 15 µM substrate, using an incubation time of 5 min) Vmax: 15 pmol/min/pmol CYP Km: 15 μM |
Usage : | For laboratory (research) purposes only |
Storage : | Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice. |
Concentration : | P450 Concentration: 2.8 nmol/ml Protein Concentration: 9.4 mg/ml Specific P450 Content: 298 pmol/mg protein |
Storage Buffer : | 50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA |
Gene Name : | CYP2C9 cytochrome P450 family 2 subfamily C member 9 [ Macaca fascicularis (crab-eating macaque) ] |
Official Symbol : | CYP2C9 |
Synonyms : | CYP2C9; cytochrome P450 family 2 subfamily C member 9; CYP2C43; cytochrome P450 2C9-like; cytochrome P450 family 2 subfamily C member 9; cytochrome P450 2C43; cytochrome P450, family 2, subfamily C, polypeptide 9 |
Gene ID : | 102115450 |
mRNA Refseq : | NM_001287625 |
Protein Refseq : | NP_001274554 |
UniProt ID : | Q0HA18 |
Products Types
◆ Recombinant Protein | ||
CYP2C9-74H | Active Recombinant Human CYP2C9 Protein | +Inquiry |
CYP2C9-976R | Recombinant Rhesus Macaque CYP2C9 Protein, His (Fc)-Avi-tagged | +Inquiry |
CYP2C9-22H | Active Recombinant Human CYP2C9 Protein | +Inquiry |
CYP2C9-544H | Active Recombinant Human CYP2C9 2 (R144C) | +Inquiry |
CYP2C9-531H | Recombinant Human CYP2C9 protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
CYP2C9-7113HCL | Recombinant Human CYP2C9 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2117 | Cytochrome P450 2C9 Inhibitor Screening Kit | +Inquiry |
Kit-2116 | Cytochrome P450 2C9 Activity Fluorometric Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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