Recombinant Cynomolgus CYP2C9 Protein CYP2C9-125C

Recombinant Cynomolgus CYP2C9 Protein

PRODUCTS

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Apply For A Coupon

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Cat.No. :	CYP2C9-125C
Product Overview :	Recombinant cynomolgus CYP2C9 protein and human CYP-reductase without tag were coexpressed in E. coli.
Description :	CYP2C9 mediated oxidation of valproate, which is the minor metabolic pathway in adults, appears to become the principal route in children. Genetic and non-genetic variations in CYP2C9 activity can result in significant inter- and intra-individual differences in valproate pharmacokinetics and valproate induced adverse reactions.
Source :	E. coli
Species :	Cynomolgus
Bio-activity :	Cytochrome c Reductase Activity: 191 nmol/min/mg protein P450 Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 50 mM potassium phosphate buffer (pH 7.4) containing 5 mM magnesium chloride and an NADPH generating system [5 mM glucose 6-phosphate, 1 mM NADP+, 1 U/ml glucose 6-phosphate dehydrogenase]) Activity: Testosterone 17-oxidase Linear with time up to: 30 min(Determined at 15 µM substrate, using a P450 concentration of 10 pmol/ml) Linear with P450 up to: 50 pmol/ml(Determined at 15 µM substrate, using an incubation time of 5 min) Vmax: 15 pmol/min/pmol CYP Km: 15 μM
Usage :	For laboratory (research) purposes only
Storage :	Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice.
Concentration :	P450 Concentration: 2.8 nmol/ml Protein Concentration: 9.4 mg/ml Specific P450 Content: 298 pmol/mg protein
Storage Buffer :	50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA

Gene Name :	CYP2C9 cytochrome P450 family 2 subfamily C member 9 [ Macaca fascicularis (crab-eating macaque) ]
Official Symbol :	CYP2C9
Synonyms :	CYP2C9; cytochrome P450 family 2 subfamily C member 9; CYP2C43; cytochrome P450 2C9-like; cytochrome P450 family 2 subfamily C member 9; cytochrome P450 2C43; cytochrome P450, family 2, subfamily C, polypeptide 9
Gene ID :	102115450
mRNA Refseq :	NM_001287625
Protein Refseq :	NP_001274554
UniProt ID :	Q0HA18