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Recombinant Escherichia coli (strain UTI89/UPEC) clpP protein (ATP-dependent Clp protease proteolytic subunit), His/Myc-tagged

Cat.No. : CLPP-1032E
Product Overview : Recombinant Escherichia coli (strain UTI89/UPEC) clpP protein (ATP-dependent Clp protease proteolytic subunit, 15-207aa), fused to 10×His-tag at N-terminus and Myc-tag at C-terminus, was expressed in human 293 cells (HEK293).
  • Specification
  • Gene Information
  • Related Products
Description : ClpP can simultaneously bind ClpX and ClpA to form a heteromeric complex. ClpP is a serine protease with a chymotrypsin-like activity that is a part of the ClpAP, ClpAPX and ClpXP protease complexes. Cleaves peptides in various proteins in a process that requires ATP hydrolysis. The protein has a chymotrypsin-like activity and plays a major role in the degradation of misfolded proteins.
Source : E.coli
Species : E.coli
Tag : His/Myc
Form : Tris-based buffer,50% glycerol.
Molecular Mass : 28.6 kDa
Protein length : 193
AA Sequence : ALVPMVIEQTSRGERSFDIYSRLLK ERVIFLTGQVEDHMANLIVAQMLFL EAENPEKDIYLYINSPGGVITAGMS IYDTMQFIKPDVSTICMGQAASMGA FLLTAGAKGKRFCLPNSRVMIHQPL GGYQGQATDIEIHAREILKVKGRMN ELMALHTGQSLEQIERDTERDRFLS APEAVEYGLVDSILTHRN
Purity : Greater than 85% as determined by SDS-PAGE.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20/-80 centigrade. The shelf life of lyophilized form is 12 months at -20/-80 centigrade. Store working aliquots at 4 centigrade for up to one week.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 mg/ml. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.
Warning : Repeated freezing and thawing is not recommended.
Synonyms : ECK0431; lopP
UniProt ID : Q1RF98
Synonyms : ECK0431; lopP
UniProt ID : Q1RF98

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there any potential therapeutic approaches targeting CLPP? 08/06/2022

Targeting CLPP therapeutically could offer potential in diseases related to mitochondrial dysfunction and aging.

How is the activity of CLPP regulated within the cell? 08/05/2020

CLPP activity is tightly regulated to ensure balanced protein turnover in mitochondria.

In which conditions is CLPP dysregulation observed, and what are its implications? 07/01/2020

Dysregulation of CLPP is linked to various diseases, including mitochondrial disorders.

How does CLPP contribute to mitochondrial protein quality control? 12/21/2019

It helps in degrading misfolded or damaged proteins, maintaining mitochondrial function.

What role does CLPP play in mitochondrial function and health? 07/27/2018

Proper functioning of CLPP is vital for mitochondrial health and energy production.

What is the significance of CLPP in aging and longevity? 07/26/2018

CLPP levels and activity are associated with aging, influencing cellular senescence and longevity.

What is the main function of CLPP in cellular processes? 05/13/2018

CLPP plays a crucial role in mitochondrial protein degradation and quality control.

Customer Reviews (3)

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Reviews
05/03/2022

    Very high purity level.

    11/15/2019

      Worked excellently in experiments.

      08/05/2018

        Product was well packaged.

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