Recombinant Full Length Human ABCC8 Protein, C-Flag-tagged
Cat.No. : | ABCC8-811HFL |
Product Overview : | Recombinant Full Length Human ABCC8 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations in the ABCC8 gene and deficiencies in the encoded protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 176.8 kDa |
AA Sequence : | MPLAFCGSENHSAAYRVDQGVLNNG CFVDALNVVPHVFLLFITFPILFIG WGSQSSKVHIHHSTWLHFPG HNLRWILTFMLLFVLVCEIAEGILS DGVTESHHLHLYMPAGMAFMAAVTS VVYYHNIETSNFPKLLIALL VYWTLAFITKTIKFVKFLDHAIGFS QLRFCLTGLLVILYGMLLLVEVNVI RVRRYIFFKTPREVKPPEDL QDLGVRFLQPFVNLLSKGTYWWMNA FIKTAHKKPIDLRAIGKLPIAMRAL TNYQRLCEAFDAQVRKDIQG TQGARAIWQALSHAFGRRLVLSSTF RILADLLGFAGPLCIFGIVDHLGKE NDVFQPKTQFLGVYFVSSQE FLANAYVLAVLLFLALLLQRTFLQA SYYVAIETGINLRGAIQTKIYNKIM HLSTSNLSMGEMTAGQICNL VAIDTNQLMWFFFLCPNLWAMPVQI IVGVILLYYILGVSALIGAAVIILL APVQYFVATKLSQAQRSTLE YSNERLKQTNEMLRGIKLLKLYAWE NIFRTRVETTRRKEMTSLRAFAIYT SISIFMNTAIPIAAVLITFV GHVSFFKEADFSPSVAFASLSLFHI LVTPLFLLSSVVRSTVKALVSVQKL SEFLSSAEIREEQCAPHEPT PQGPASKYQAVPLRVVNRKRPARED CRGLTGPLQSLVPSADGDADNCCVQ IMGGYFTWTPDGIPTLSNIT IRIPRGQLTMIVGQVGCGKSSLLLA ALGEMQKVSGAVFWSSLPDSEIGED PSPERETATDLDIRKRGPVA YASQKPWLLNATVEENIIFESPFNK QRYKMVIEACSLQPDIDILPHGDQT QIGERGINLSGGQRQRISVA RALYQHANVVFLDDPFSALDIHLSD HLMQAGILELLRDDKRTVVLVTHKL QYLPHADWIIAMKDGTIQRE GTLKDFQRSECQLFEHWKTLMNRQD QELEKETVTERKATEPPQGLSRAMS SRDGLLQDEEEEEEEAAESE EDDNLSSMLHQRAEIPWRACAKYLS SAGILLLSLLVFSQLLKHMVLVAID YWLAKWTDSALTLTPAARNC SLSQECTLDQTVYAMVFTVLCSLGI VLCLVTSVTVEWTGLKVAKRLHRSL LNRIILAPMRFFETTPLGSI LNRFSSDCNTIDQHIPSTLECLSRS TLLCVSALAVISYVTPVFLVALLPL AIVCYFIQKYFRVASRDLQQ LDDTTQLPLLSHFAETVEGLTTIRA FRYEARFQQKLLEYTDSNNIASLFL TAANRWLEVRMEYIGACVVL IAAVTSISNSLHRELSAGLVGLGLT YALMVSNYLNWMVRNLADMELQLGA VKRIHGLLKTEAESYEGLLA PSLIPKNWPDQGKIQIQNLSVRYDS SLKPVLKHVNALIAPGQKIGICGRT GSGKSSFSLAFFRMVDTFEG HIIIDGIDIAKLPLHTLRSRLSIIL QDPVLFSGTIRFNLDPERKCSDSTL WEALEIAQLKLVVKALPGGL DAIITEGGENFSQGQRQLFCLARAF VRKTSIFIMDEATASIDMATENILQ KVVMTAFADRTVVTIAHRVH TILSADLVIVLKRGAILEFDKPEKL LSRKDSVFASFVRADKTRTRPLEQK LISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Transmembrane |
Protein Pathways : | ABC transporters, Type II diabetes mellitus |
Gene Name : | ABCC8 ATP binding cassette subfamily C member 8 [ Homo sapiens (human) ] |
Official Symbol : | ABCC8 |
Synonyms : | HI; SUR; HHF1; MRP8; PHHI; SUR1; ABC36; HRINS; PNDM3; TNDM2; SUR1delta2 |
Gene ID : | 6833 |
mRNA Refseq : | NM_000352.6 |
Protein Refseq : | NP_000343.2 |
MIM : | 600509 |
UniProt ID : | Q09428 |
Products Types
◆ Recombinant Protein | ||
ABCC8-592H | Recombinant Human ABCC8 Protein, Myc/DDK-tagged | +Inquiry |
ABCC8-243H | Recombinant Human ABCC8 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABCC8-63R | Recombinant Rat ABCC8 Protein, His (Fc)-Avi-tagged | +Inquiry |
Abcc8-1460M | Recombinant Mouse Abcc8 Protein, Myc/DDK-tagged | +Inquiry |
ABCC8-238H | Recombinant Human ABCC8 Protein, MYC/DDK-tagged | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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