Recombinant Full Length Human ARPC1B Protein, C-Flag-tagged

• Cat.No.: ARPC1B-2019HFL
• Product Overview: Recombinant Full Length Human ARPC1B Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 40.8 kDa
• AA Sequence: MAYHSFLVEPISCHAWNKDRTQIAI CPNNHEVHIYEKSGAKWTKVHELKE HNGQVTGIDWAPESNRIVTC GTDRNAYVWTLKGRTWKPTLVILRI NRAARCVRWAPNENKFAVGSGSRVI SICYFEQENDWWVCKHIKKP IRSTVLSLDWHPNNVLLAAGSCDFK CRIFSAYIKEVEERPAPTPWGSKMP FGELMFESSSSCGWVHGVCF SASGSRVAWVSHDSTVCLADADKKM AVATLASETLPLLALTFITDNSLVA AGHDCFPVLFTYDAAAGMLS FGGRLDVPKQSSQRGLTARERFQNL DKKASSEGGTAAGAGLDSLHKNSVS QISVLSGGKAKCSQFCTTGM DGGMSIWDVKSLESALKDLKIK TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Pathways: Fc gamma R-mediated phagocytosis, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton

Gene Information

• Gene Name: ARPC1B actin related protein 2/3 complex subunit 1B [ Homo sapiens (human) ]
• Official Symbol: ARPC1B
• Synonyms: ARC41; IMD71; PLTEID; p40-ARC; p41-ARC
• Gene ID: 10095
• mRNA Refseq: NM_005720.4
• Protein Refseq: NP_005711.1
• MIM: 604223
• UniProt ID: O15143