Recombinant Full Length Human ASGR1 Protein, C-Flag-tagged

• Cat.No.: ASGR1-1224HFL
• Product Overview: Recombinant Full Length Human ASGR1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 33 kDa
• AA Sequence: MTKEYQDLQHLDNEESDHHQLRKGP PPPQPLLQRLCSGPRLLLLSLGLSL LLLVVVCVIGSQNSQLQEEL RGLRETFSNFTASTEAQVKGLSTQG GNVGRKMKSLESQLEKQQKDLSEDH SSLLLHVKQFVSDLRSLSCQ MAALQGNGSERTCCPVNWVEHERSC YWFSRSGKAWADADNYCRLEDAHLV VVTSWEEQKFVQHHIGPVNT WMGLHDQNGPWKWVDGTDYETGFKN WRPEQPDDWYGHGLGGGEDCAHFTD DGRWNDDVCQRPYRWVCETE
  LDKASQEPPLLTRTRPLEQKLISEE DLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane

Gene Information

• Gene Name: ASGR1 asialoglycoprotein receptor 1 [ Homo sapiens (human) ]
• Official Symbol: ASGR1
• Synonyms: HL-1; ASGPR; ASGPR1; CLEC4H1
• Gene ID: 432
• mRNA Refseq: NM_001671.5
• Protein Refseq: NP_001662.1
• MIM: 108360
• UniProt ID: P07306