| Description : |
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.[provided by RefSeq, Jul 2014] |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Tag : |
GST |
| Molecular Mass : |
70.3 kDa |
| Protein Length : |
384 amino acids |
| AA Sequence : |
MKEYVLLLFL ALCSAKPFFS PSHIALKNMM LKDMEDTDDD DDDDDDDDDD DDDDEEDNSL FPTREPRSHF FPFDLFPMCP FGCQCYSRVV HCSDLGLTSV PTNIPFDTRM LDLQNNKIKE IKENDFKGLT SLYGLILNNN KLTKIHPKAF LTTKKLRRLY LSHNQLSEIP LNLPKSLAEL RIHENKVKKI QKDTFKGMNA LHVLEMSANP LDNNGIEPGA FEGVTVFHIR IAEAKLTSVP KGLPPTLLEL HLDYNKISTV ELEDFKRYKE LQRLGLGNNK ITDIENGSLA NIPRVREIHL ENNKLKKIPS GLPELKYLQI IFLHSNSIAR VGVNDFCPTV PKMKKSLYSA ISLFNNPVKY WEMQPATFRC VLSRMSVQLG NFGM |
| Applications : |
Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
