| Description : |
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012] |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Tag : |
GST |
| Molecular Mass : |
100.21 kDa |
| Protein Length : |
671 amino acids |
| AA Sequence : |
MSKNPSGKNR ETVPIKDNFE LEVLQAQYKE LKEKMKVMEE EVLIKNGEIK ILRDSLHQTE SVLEEQRRSH FLLEQEKTQA LSDKEKEFSK KLQSLQSELQ FKDAEMNELR TKLQTSERAN KLAAPSVSHV SPRKNPSVVI KPEACSPQFG KTSFPTKESF SANMSLPHPC QTESGYKPLV GREDSKLHSL RGDSIKQEEA QKSFVDSWRQ RSNTQGSILI NLLLKQPLIP GSSLSLCHLL SSSSESPAGT PLQPPGFGST LAGMSGLRTT GSYDGSFSLS ALREAQNLAF TGLNLVARNE CSRDGDPAEG GRRAFPLCQL PGAVHFLPLV QFFIGLHCQA LQDLAAAKRS GAPGDSPTHS SCVSSGVETN PEDSVCILEG FSVTALSILQ HLVCHSGAVV SLLLSGVGAD SAAGEGNRSL VHRLSDGDMT SALRGVADDQ GQHPLLKMLL HLLAFSSAAT GHLQASVLTQ CLKVLVKLAE NTSCDFLPRF QCVFQVLPKC LSPETPLPSV LLAVELLSLL ADHDQLAPQL CSHSEGCLLL LLYMYITSRP DRVALETQWL QLEQEVVRAL TVMLHRQWLT VRRAGGPPRT DQQRRTVRCL RDTVLLLHGL SQKDKLFMMH CVEVLHQFDQ VMPGVSMLIR GLPDVTDCEE AALDDLCAAE TDVEDPEVEC G |
| Applications : |
Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
