| Description : |
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
85.7 kDa |
| AA Sequence : |
MAGTSAPGSKRRSEPPAPRPGPPPG TGHPPSKRARGFSAAAAPDPDDPFG AHGDFTADDLEELDTLASQALSQCP AAARDVSSDHKVHRLLDGMSKNPSG KNRETVPIKDNFELEVLQAQYKELK EKMKVMEEEVLIKNGEIKILRDSLH QTESVLEEQRRSHFLLEQEKTQALS DKEKEFSKKLQSLQSELQFKDAEMN ELRTKLQTSERANKLAAPSVSHVSP RKNPSVVIKPEACSPQFGKTSFPTK ESFSANMSLPHPCQTESGYKPLVGR EDSKPHSLRGDSIKQEEAQKSFVDS WRQRSNTQGSILINLLLKQPLIPGS SLSLCHLLSSSSESPAGTPLQPPGF GSTLAGMSGLRTTGSYDGSFSLSAL REAQNLAFTGLNLVARNECSRDGDP AEGGRRAFPLCQLPGAVHFLPLVQF FIGLHCQALQDLAAAKRSGAPGDSP THSSCVSSGVETNPEDSVCILEGFS VTALSILQHLVCHSGAVVSLLLSGV GADSAAGEGNRSLVHRLSDGDMTSA LRGVADDQGQHPLLKMLLHLLAFSS AATGHLQASVLTQCLKVLVKLAENT SCDFLPRFQCVFQVLPKCLSPETPL PSVLLAVELLSLLADHDQLAPQLCS HSEGCLLLLLYMYITSRPDRVALET QWLQLEQEVVWLLAKLGVQSPLPPV TGSNCQCNVEVVRALTVMLHRQWLT VRRAGGPPRTDQQRRTVRCLRDTVL LLHGLSQKDKLFMMHCVEVLHQFDQ VMPGVSMLIRGLPDVTDCEEAALDD LCAAETDVEDPEVECGTRTRPLEQK LISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
