| Description : |
This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Tag : |
GST |
| Form : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
| Molecular Mass : |
102.4 kDa |
| Protein Length : |
685 amino acids |
| AA Sequence : |
MLWFSGVGALAERYCRRSPGITCCV LLLLNCSGVPMSLASSFLTGSVAKC ENEGEVLQIPFITDNPCIMCVCLNK EVTCKREKCPVLSRDCALAIKQRGA CCEQCKGCTYEGNTYNSSFKWQSPA EPCVLRQCQEGVVTESGVRCVVHCK NPLEHLGMCCPTCPGCVFEGVQYQE GEEFQPEGSKCTKCSCTGGRTQCVR EVCPILSCPQHLSHIPPGQCCPKCL GQRKVFDLPFGSCLFRSDVYDNGSS FLYDNCTACTCRDSTVVCKRKCSHP GGCDQGQEGCCEECLLRVPPEDIKV CKFGNKIFQDGEMWSSINCTICACV KGRTECRNKQCIPISSCPQGKILNR KGCCPICTEKPGVCTVFGDPHYNTF DGRTFNFQGTCQYVLTKDCSSPASP FQVLVKNDARRTRSFSWTKSVELVL GESRVSLQQHLTVRWNGSRIALPCR APHFHIDLDGYLLKVTTKAGLEISW DGDSFVEVMAAPHLKGKLCGLCGNY NGHKRDDLIGGDGNFKFDVDDFAES WRVESNEFCNRPQRKPVPELCQGTV KVKLRAHRECQKLKSWEFQTCHSTV DYATFYRSCVTDMCECPVHKNCYCE SFLAYTRACQREGIKVHWEPQQNCA ATQCKHGAVYDTCGPGCIKTCDNWN EIGPCNKPCVAGCHCPANLVLHKGR CIKPVLCPQR |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
