Recombinant Full Length Human CASK Protein, C-Flag-tagged

• Cat.No.: CASK-1552HFL
• Product Overview: Recombinant Full Length Human CASK Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, intellectual disability and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked intellectual disability. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 104.3 kDa
• AA Sequence: MADDDVLFEDVYELCEVIGKGPFSV VRRCINRETGQQFAVKIVDVAKFTS SPGLSTEDLKREASICHMLK HPHIVELLETYSSDGMLYMVFEFMD GADLCFEIVKRADAGFVYSEAVASH YMRQILEALRYCHDNNIIHR DVKPHCVLLASKENSAPVKLGGFGV AIQLGESGLVAGGRVGTPHFMAPEV VKREPYGKPVDVWGCGVILF ILLSGCLPFYGTKERLFEGIIKGKY KMNPRQWSHISESAKDLVRRMLMLD PAERITVYEALNHPWLKERD RYAYKIHLPETVEQLRKFNARRKLK GAVLAAVSSHKFNSFYGDPPEELPD FSEDPTSSGLLAAERAVSQV LDSLEEIHALTDCSEKDLDFLHSVF QDQHLHTLLDLYDKINTKSSPQIRN PPSDAVQRAKEVLEEISCYP ENNDAKELKRILTQPHFMALLQTHD VVAHEVYSDEALRVTPPPTSPYLNG DSPESANGDMDMENVTRVRL VQFQKNTDEPMGITLKMNELNHCIV ARIMHGGMIHRQGTLHVGDEIREIN GISVANQTVEQLQKMLREMR GSITFKIVPSYRTQSSSCERDSPST SRQSPANGHSSTNNSVSDLPSTTQP KGRQIYVRAQFEYDPAKDDL IPCKEAGIRFRVGDIIQIISKDDHN WWQGKLENSKNGTAGLIPSPELQEW RVACIAMEKTKQEQQASCTW FGKKKKQYKDKYLAKHNAVFDQLDL VTYEEVVKLPAFKRKTLVLLGAHGV GRRHIKNTLITKHPDRFAYP IPHTTRPPKKDEENGKNYYFVSHDQ MMQDISNNEYLEYGSHEDAMYGTKL ETIRKIHEQGLIAILDVEPQ ALKVLRTAEFAPFVVFIAAPTITPG LNEDESLQRLQKESDILQRTYAHYF DLTIINNEIDETIRHLEEAV
  ELVCTAPQWVPVSWVYTRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Tight junction

Gene Information

• Gene Name: CASK calcium/calmodulin dependent serine protein kinase [ Homo sapiens (human) ]
• Official Symbol: CASK
• Synonyms: CMG; FGS4; LIN2; TNRC8; hCASK; CAGH39; CAMGUK; MICPCH; MRXSNA
• Gene ID: 8573
• mRNA Refseq: NM_003688.4
• Protein Refseq: NP_003679.2
• MIM: 300172
• UniProt ID: O14936