Recombinant Full Length Human CD27 Protein, C-Flag-tagged

• Cat.No.: CD27-1418HFL
• Product Overview: Recombinant Full Length Human CD27 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 26.9 kDa
• AA Sequence: MARPHPWWLCVLGTLVGLSATPAPK SCPERHYWAQGKLCCQMCEPGTFLV KDCDQHRKAAQCDPCIPGVS FSPDHHTRPHCESCRHCNSGLLVRN CTITANAECACRNGWQCRDKECTEC DPLPNPSLTARSSQALSPHP QPTHLPYVSEMLEARTAGHMQTLAD FRQLPARTLSTHWPPQRSLCSSDFI RILVIFSGMFLVFTLAGALF
  LHQRRKYRSNKGESPVEPAEPCRYS CPREEEGSTIPIQEDYRKPEPACSP TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction

Gene Information

• Gene Name: CD27 CD27 molecule [ Homo sapiens (human) ]
• Official Symbol: CD27
• Synonyms: T14; S152; Tp55; TNFRSF7; S152. LPFS2
• Gene ID: 939
• mRNA Refseq: NM_001242.5
• Protein Refseq: NP_001233.2
• MIM: 186711
• UniProt ID: P26842