Recombinant Full Length Human Egf-Like Module-Containing Mucin-Like Hormone Receptor-Like 2(Emr2) Protein, His-Tagged

• Cat.No.: RFL18854HF
• Product Overview: Recombinant Full Length Human EGF-like module-containing mucin-like hormone receptor-like 2(EMR2) Protein (Q9UHX3) (24-823aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Homo sapiens (Human)
• Tag: His
• Form: Lyophilized powder
• Protein Length: Full Length of Mature Protein (24-823)
• AA Sequence: QDSRGCARWCPQDSSCVNATACRCN PGFSSFSEIITTPMETCDDINECAT LSKVSCGKFS DCWNTEGSYDCVCSPGYEPVSGAKT FKNESENTCQDVDECQQNPRLCKSY GTCVNTLGSY TCQCLPGFKLKPEDPKLCTDVNECT SGQNPCHSSTHCLNNVGSYQCRCRP GWQPIPGSPN GPNNTVCEDVDECSSGQHQCDSSTV CFNTVGSYSCRCRPGWKPRHGIPNN QKDTVCEDMT FSTWTPPPGVHSQTLSRFFDKVQDL GRDYKPGLANNTIQSILQALDELLE APGDLETLPR LQQHCVASHLLDGLEDVLRGLSKNL SNGLLNFSYPAGTELSLEVQKQVDR SVTLRQNQAV MQLDWNQAQKSGDPGPSVVGLVSIP GMGKLLAEAPLVLEPEKQMLLHETH QGLLQDGSPI LLSDVISAFLSNNDTQNLSSPVTFT FSHRSVIPRQKVLCVFWEHGQNGCG HWATTGCSTI GTRDTSTICRCTHLSSFAVLMAHYD VQEEDPVLTVITYMGLSVSLLCLLL AALTFLLCKA IQNTSTSLHLQLSLCLFLAHLLFLV AIDQTGHKVLCSIIAGTLHYLYLAT LTWMLLEALY LFLTARNLTVVNYSSINRFMKKLMF PVGYGVPAVTVAISAASRPHLYGTP SRCWLQPEKG FIWGFLGPVCAIFSVNLVLFLVTLW ILKNRLSSLNSEVSTLRNTRMLAFK ATAQLFILGC TWCLGILQVGPAARVMAYLFTIINS LQGVFIFLVYCLLSQQVREQYGKWS KGIRKLKTES EMHTLSSSAKADTSKPSTVN
• Purity: Greater than 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: ADGRE2
• Synonyms: ADGRE2; EMR2; Adhesion G protein-coupled receptor E2; EGF-like module receptor 2; EGF-like module-containing mucin-like hormone receptor-like 2; CD antigen CD312
• UniProt ID: Q9UHX3

Gene Information

• Gene Name: ADGRE2
• Synonyms: ADGRE2; EMR2; Adhesion G protein-coupled receptor E2; EGF-like module receptor 2; EGF-like module-containing mucin-like hormone receptor-like 2; CD antigen CD312
• UniProt ID: Q9UHX3

Reviews

09/24/2021

Demonstrates excellent stability and consistency in long-term storage.

03/15/2021

Provides accurate and reproducible quantification of the target protein in mass spectrometry analysis.

Q&As

Does ADGRE2 play a role in immune cell activation, migration, or adhesion, and what are the underlying mechanisms?

ADGRE2 plays a role in immune cell activation, migration, and adhesion through mechanisms involving [specific cellular processes or adhesion molecules].

What are the functional consequences of ADGRE2 activation or inhibition on immune cell function and immune responses?

Activation or inhibition of ADGRE2 has functional consequences on immune cell function and immune responses, impacting [specific immune cell activities or immune response outcomes].

What are the downstream signaling pathways activated by ADGRE2 and how do they contribute to cellular processes?

ADGRE2 activates specific downstream signaling pathways, including [specific signaling cascades], which contribute to various cellular processes, such as [specific immune cell activation or migration].

Are there any known ligands or interacting partners that bind to the ADGRE2 protein and modulate its function?

ADGRE2 interacts with specific ligands or interacting partners, such as [specific molecules or cell surface receptors], leading to the modulation of its function.

Can the expression or activity of ADGRE2 be modulated by pharmacological agents or genetic manipulation?

The expression or activity of ADGRE2 can be modulated by pharmacological agents that target [specific receptors or signaling pathways], or through genetic manipulation using [specific genetic tools or techniques].

What is the impact of ADGRE2 deficiency or knockout on immune cell phenotypes or immune responses?

Deficiency or knockout of ADGRE2 in immune cells leads to observable changes in immune cell phenotypes or altered immune responses, characterized by [specific immune cell dysfunctions or immune response impairments].

Does ADGRE2 play a role in specific diseases or pathological conditions, and if so, what are the associated mechanisms?

ADGRE2 is implicated in specific diseases or pathological conditions, such as [specific autoimmune diseases or inflammatory disorders], where it contributes to [specific disease mechanisms or immune dysregulation].

What is the subcellular localization and distribution pattern of ADGRE2 within immune cells or relevant cell types?

ADGRE2 exhibits a [specific subcellular localization pattern], with localization primarily observed in [specific cellular compartments, such as plasma membrane or endosomes].

How is the expression of ADGRE2 regulated under normal physiological conditions and in response to specific stimuli?

Under normal physiological conditions, the expression of ADGRE2 is tightly regulated and can be modulated in response to specific stimuli, such as [specific cytokines or inflammatory signals].

What is the tissue-specific expression pattern of the ADGRE2 protein across different organs and cell types?

The ADGRE2 protein exhibits a specific expression pattern across various tissues and cell types, with higher levels observed in [specific tissues or cell populations].