Recombinant Full Length Human FANCL (I309S) Protein, GST tagged

• Cat.No.: FANCL-026H
• Product Overview: Recombinant full-length human FANCL (I309S) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 1-375 aa
• Description: This gene encodes a ubiquitin ligase that is a member of the Fanconi anemia complementation group (FANC). Members of this group are related by their assembly into a common nuclear protein complex rather than by sequence similarity. This gene encodes the protein for complementation group L that mediates monoubiquitination of FANCD2 as well as FANCI. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Alternative splicing results in multiple transcript variants.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 1mM DTT, 10% glycerol.
• Molecular Mass: ~69 kDa
• Purity: > 70% by densitometry.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. 1yr at –70 centigrade from date of shipment.
• Concentration: 0.1 μg/μL
• Shipping: Dry Ice
• Reference: 1. Meetei.et.al: A novel ubiquitin ligase is deficient in Fanconi anemia. Nature Genet. 35: 165-170, 2003. 2. Zhang, Y.et.al: UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2. Molec. Cells 31: 113-122, 2011.

Gene Information

• Gene Name: FANCL Fanconi anemia, complementation group L [ Homo sapiens (human) ]
• Official Symbol: FANCL
• Synonyms: FANCL; Fanconi anemia, complementation group L; PHD finger protein 9, PHF9; E3 ubiquitin-protein ligase FANCL; FAAP43; FLJ10335; Pog; PHD finger protein 9; fanconi anemia group L protein; fanconi anemia-ass centigradeiated polypeptide of 43 kDa; POG; PHF9
• Gene ID: 55120
• mRNA Refseq: NM_018062
• Protein Refseq: NP_060532
• MIM: 608111
• UniProt ID: Q9NW38