Recombinant Full Length Human GATM Protein, C-Flag-tagged

• Cat.No.: GATM-833HFL
• Product Overview: Recombinant Full Length Human GATM Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by cognitive disability, language impairment, and behavioral disorders.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 44.2 kDa
• AA Sequence: MLRVRCLRGGSRGAEAVHYIGSRLG RTLTGWVQRTFQSTQAATASSRNSC AADDKATEPLPKDCPVSSYN EWDPLEEVIVGRAENACVPPFTIEV KANTYEKYWPFYQKQGGHYFPKDHL KKAVAEIEEMCNILKTEGVT VRRPDPIDWSLKYKTPDFESTGLYS AMPRDILIVVGNEIIEAPMAWRSRF FEYRAYRSIIKDYFHRGAKW TTAPKPTMADELYNQDYPIHSVEDR HKLAAQGKFVTTEFEPCFDAADFIR AGRDIFAQRSQVTNYLGIEW MRRHLAPDYRVHIISFKDPNPMHID ATFNIIGPGIVLSNPDRPCHQIDLF KKAGWTIITPPTPIIPDDHP LWMSSKWLSMNVLMLDEKRVMVDAN EVPIQKMFEKLGITTIKVNIRNANS LGGGFHCWTCDVRRRGTLQS
  YLDTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Arginine and proline metabolism, Glycine, serine and threonine metabolism, Metabolic pathways

Gene Information

• Gene Name: GATM glycine amidinotransferase [ Homo sapiens (human) ]
• Official Symbol: GATM
• Synonyms: AT; AGAT; CCDS3; FRTS1
• Gene ID: 2628
• mRNA Refseq: NM_001482.3
• Protein Refseq: NP_001473.1
• MIM: 602360
• UniProt ID: P50440