Recombinant Full Length Human GCLC Protein

• Cat.No.: GCLC-192HF
• Product Overview: Recombinant full length Human GCLC with a proprietary tag; Predicted MWt 96.14.

Specification

• Description: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 96.140kDa inclusive of tags
• Protein Length: 637 amino acids
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: GCLC glutamate-cysteine ligase, catalytic subunit [ Homo sapiens ]
• Official Symbol: GCLC
• Synonyms: GCLC; glutamate-cysteine ligase, catalytic subunit; GLCL, GLCLC; glutamate--cysteine ligase catalytic subunit; GCS
• Gene ID: 2729
• mRNA Refseq: NM_001197115
• Protein Refseq: NP_001184044
• MIM: 606857
• UniProt ID: P48506